hypertension and high blood pressure

	Hypertension And High Blood Pressure Understanding Hypertension And High Blood Pressure Hypertension And Massage What Causes Hypertension
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	the group of diseases that affect the heart and the blood vessels throughout the body.

	Description of the feeding dynamics of institutionalized elderly women CONCLUSION: Environmental, cognitive and behavioral factors related to feeding were significantly present among the subjects of the study, putting deglutition at risk. Other specific deglutition difficulties were also identified. Managing these difficulties is important, in order to avoid health complications for elderly women. (Source: Revista da Sociedade Brasileira de Fonoaudiologia)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Sleep Duration and Cardiovascular Disease: Results from the National Health Interview Survey Conclusion: Compared with sleep duration of 7 h, there was a positive association between both shorter and longer sleep durations and CVD in a representative sample of US adults. These results suggest that sleep duration may be an important marker of CVD. Keywords: Sleep, sleep duration, cardiovascular disease, NHIS (Source: Sleep) The Effects of Sleep-Disordered Breathing on Arterial Stiffness are Modulated by Age Conclusions: Adverse effects of nocturnal oxygen desaturation on PWV are seen among normotensive individuals and are amplified with aging. Integrated assessment of SDB is necessary to characterize its effects on arterial stiffness. Keywords: Arteries, hypertension, sleep apnea, vascular disease (Source: Sleep) Mechanisms underlying uremic encephalopathy Em pacientes com insuficiência renal, a encefalopatia é um problema comum que pode ser provocado pela uremia, deficiência de tiamina, diálise, rejeição de transplante, hipertensão, desequilíbrios hidroeletrolíticos e toxicidades medicamentosas. Em geral a encefalopatia se apresenta como um complexo de sintomas que progride de uma leve obnubilação sensitiva até delírio e coma. Esta revisão discute questões importantes com relação aos mecanismos de base da fisiopatologia da encefalopatia urêmica. A fisiopatologia da encefalopatia urêmica é até hoje incerta, mas postula-se o envolvimento de diversos fatores; trata-se de um processo complexo e provavelmente multifatorial. Distúrbios hormonais, estresse oxidativo, acúmulo de metabólitos, desequilíbrio entre os neurotran... Woman saves her own life by losing 200 pounds Marci Williams, at 332 pounds in 2005, had diabetes, high cholesterol and high blood pressure. Her cardiologist told her it all came back to ... (Source: USATODAY.com Health) This column will change your life: Forgiveness If hanging on to old resentments is bad for your health, what's the solution?Nothing in the lexicon of popular psychology triggers my inbuilt wince response quite so powerfully as the word "forgiveness". Apart from sheer cheesiness ? it's hardly unique in that respect, sadly ? there are several problems with the way self-help pontificators are always advising us to forgive. First, it seems like a concept best reserved for those who've undergone real trauma; I bridle, for example, at the "forgiveness guru" Colin Tipping's insistence that we all need to forgive our parents, apparently even if they were good parents ? as if not resenting them sufficiently were some kind of failing. Second, declaring yourself to have forgiven someone can sometimes be the height of pomposity, ev...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum Ureaplasma species, the most commonly isolated microorganisms in women with chorioamnionitis, are associated with preterm delivery. Chorioamnionitis increases the risk and severity of bronchopulmonary dysplasia and persistent pulmonary hypertension in newborns. It is not known whether the timing of exposure to inflammation in utero is an important contributor to the pathogenesis of bronchopulmonary dysplasia. We hypothesized that chronic inflammation would alter the pulmonary air space and vascular development after 70 days of exposure to infection. Pregnant ewes were given intra-amniotic injection of Ureaplasma parvum serovars 3 or 6 at low (2 x 104 cfu) or high doses (2 x 107 cfu) or media (controls) at 55 days gestational age. Fetuses were delivered at 125 days (term = 150 days). U. par... Effect of enalapril on plasma homocysteine levels in patients with essential hypertension. Conclusions: Enalapril may cause an increase in plasma Hcy levels among the hypertensives with low baseline Hcy levels. There was no significant association between MTHFR C677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension. PMID: 20669348 [PubMed - as supplied by publisher] (Source: J Zhejiang Univ Sci ...) Investigating mildly abnormal serum aminotransferase values (Source: BMJ Online First) First-line Latanoprost Therapy in Ocular Hypertension or Open-angle Glaucoma Patients: a 3-month Efficacy Analysis Stratified by Initial Intraocular Pressure How effective is latanoprost in the treatment of both glaucoma and ocular hypertension? BMC Ophthalmology (Source: Medscape Today Headlines) One third of young people suffer from high blood pressure A worrying 35 per-cent of those aged 16-34 have hypertension, despite the widespread belief that it is an 'old age' problem. (Source: the Mail online \| Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Pre-operative Gynecologic Evaluation of Bariatric Surgery Patients: Improving Cancer Detection in a High-Risk Population Conclusions: Given the massive increases in morbid obesity and bariatric surgery in women, surgeons could serve a vital role in educating patients about both gynecologic and nongynecologic malignancy risks. With appropriate referral for cancer screening, patient outcomes could improve. (Source: Journal of the American College of Surgeons) Med Sci Monit 2010; 16(8):PR9-14 "Efficacy and safety of intravenous stronger neo-minophagen C and S-adenosyl-L-methionine in treatment of pregnant woman with chronic hepatitis B: A pilot study" Conclusions: Both SNMC and SAM improve liver function, with SNMC appearing more effective, in pregnant women with chronic hepatitis B without impact on fetal development. (Source: Medical Science Monitor) Med Sci Monit 2010; 16(8):RA163-170 "Renal consequences of obesity" The worldwide prevalence of obesity and its associated metabolic and cardiovascular disorders has risen dramatically within the past 2 decades. Our objective is to review the mechanisms that link obesity with altered kidney function. Current evidence suggests that excess weight gain may be responsible for 65?75% of the risk for arterial hypertension. Impaired renal pressure natriuresis, initially due to increased renal tubular sodium reabsorption, is a key factor linking obesity with hypertension. Obesity increases renal sodium reabsorption by activating the renin-angiotensin and sympathetic nervous systems, and by altering intrarenal physical forces. Adipose tissue functions as an endocrine organ, secreting hormones/cytokines (e.g., leptin) which may trigger sodium retention and hype... Med Sci Monit 2010; 16(8):BR278-284 "Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle" Conclusions: These results suggest that hypertrophied myocardial dysfunction may be attributed to changes in intracellular calcium cycling. (Source: Medical Science Monitor) Music benefits the brain, research reveals (NaturalNews) Northwestern University scientists have pulled together a review of research into what music -- specifically, learning to play music -- does to humans. The result shows music training does far more than allow us to entertain ourselves and others by playing an instrument or singing. Instead, it actually changes our brains.The paper, just published in Nature Reviews Neuroscience, is a compilation of research findings from scientists all over the world who used all kinds of research methods. The bottom line to all these studies: musical training has a profound impact on other skills including speech and language, memory and attention, and even the ability to convey emotions vocally. So what is it that musical training does? According to the Northwestern scientists, the findings ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Spontaneous hyphaema and acute ocular hypertension associated with severe lens-induced uveitis Authors: S R Rathinam & E T Cunningham (Source: Eye) Unichem Labs gets USFDA nod for hypertension tabs Unichem Laboratories has received US FDA approval for bisoprolol fumarate and hydrochlorothiazide in tablet form, the drug regulator's website showed on Friday. Both drugs are used in the treatment of hypertension. (Source: The Economic Times Healthcare and Biotech News) Calcium supplements in people with osteoporosis (Source: BMJ Online First) Myocardial Calcification and Hypertension following Chronic Renal Failure and Ameliorative Effects of Furosemide and Captopril Cardiology 2010;116:194â€“205 (DOI:10.1159/000315146) (Source: Karger Publishers) A prospective randomized study comparing cyclosporine versus tacrolimus combined with daclizumab, mycophenolate mofetil, and steroids in heart transplantation Conclusions: Tac patients showed a tendency for longer time to first rejection, and there were more rejection-free patients with Tac and suffered fewer viral infections. Tac patients developed less hypertension and needed less drugs for its control. Renal function was similar in both groups. (Source: Clinical Transplantation)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> EDUCORE project: a clinical trial, randomised by clusters, to assess the effect of a visual learning method on blood pressure control in the primary healthcare setting Discussion, The EDUCORE method could provide a simple, inexpensive means of improving blood pressure control, and perhaps other health problems, in the primary healthcare setting; Trial registration, The trial was registered with ClinicalTrials.gov, number NCT01155973 [http://ClinicalTrials.gov]. (Source: BMC Public Health - Latest articles) Role of Endothelin and Inflammatory Cytokines in Pre-eclampsia – A Pilot North Indian Study Conclusion We conclude that pre-eclampsia is associated with increased levels of both endothelin-1 and circulating inflammatory cytokines, which points toward the role of endothelial and inflammatory components. (Source: American Journal of Reproductive Immunology) RCT: Nutritional intervention in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment - LOADD study Source: BMJ Area: News This small randomised controlled trial (RCT) aimed to investigate how much intensive dietary intervention can influence glycaemic control and risk factors for cardiovascular disease in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment. The trial participants (n=93) were randomised to either intensive individualised dietary advice (n =45) according to the nutritional recommendations of the European Association for the Study of Diabetes) for six months or standard care (n=48, control). Both the intervention and control participants continued with their usual clinical care for diabetes (general practitioner or hospital diabetes clinic). Participants were aged <70 years with type 2 diabetes and a HbA1c of >7% despite optimised t... [Comment] NO for preterm infants at risk of bronchopulmonary dysplasia Although the initial clinical application of inhaled nitric oxide was for its vasodilatory role in pulmonary hypertension in term infants, nitric oxide showed positive effects in animal models of lung immaturity and lung injury: a reduction in lung inflammation, reduction in neutrophil infiltration into the lung, protection against oxidant lung injury, reversal of the effects of inhibition of vascular endothelial growth factor, and stimulation of angiogenesis and alveolarisation. On the basis of these findings, several studies were done to test the hypothesis that inhaled nitric oxide might preserve angiogenesis and alveolarisation, and therefore reduce lung injury and bronchopulmonary dysplasia. (Source: LANCET) Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice. Authors: Cuenca N, Pinilla I, FernÃ¡ndez-SÃ¡nchez L, Salinas-Navarro M, AlarcÃ³n-MartÃnez L, AvilÃ©s-Trigueros M, de la Villa P, Miralles de Imperial J, Villegas-PÃ©rez MP, Vidal-Sanz M In adult albino mice the effects of increased intraocular pressure on the outer retina and its circuitry was investigated at intervals ranging 3-14 weeks. Ocular hypertension (OHT) was induced by cauterizing the vessels draining the anterior part of the mice eye, as recently reported (Salinas-Navarro et al., 2009a). Electroretinographic (ERG) responses were recorded simultaneously from both eyes and compared each other prior to and at different survival intervals of 2, 8 or 12 weeks after lasering. Animals were processed at 3, 9 or 14 weeks after lasering, and radial sections were obtained ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303) [Gastrointestinal Cancer] Conclusion The addition of bevacizumab to gemcitabine does not improve survival in advanced pancreatic cancer patients. (Source: Journal of Clinical Oncology) Comparison of risk of neurovascular and cardiovascular side effects between tiotropium and other anticholinergic agents. CONCLUSION: This observational study of recorded side effects showed that, except for stroke and hypertension, patients who were treated with an inhaled anticholinergic drug appeared to be at higher risk of developing neurovascular or cardiovascular side effects, than those treated with an oral drug. However, physicians should also be aware that oral anticholinergic drugs may have similar adverse impacts on health. Further studies on the association between anticholinergic drugs and cardiovascular and neurovascular side effects are recommended. PMID: 20659403 [PubMed - in process] (Source: Quality in Primary Care) NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice Sleep apnea (SA) is defined as intermittent respiratory arrest during sleep and affects up to 20% of the adult population. SA is also associated with an increased incidence of hypertension and peripheral vascular disease. Exposing rodents to intermittent hypoxia during sleep mimics the cyclical hypoxia/normoxia of SA. We have previously shown that in mice and rats intermittent hypoxia induces ET-1 upregulation and systemic hypertension. Furthermore, intermittent hypoxia (IH) in mice increases nuclear factor of activated T cells isoform 3 (NFATc3) transcriptional activity in aorta and mesenteric arteries, whereas the calcineurin/NFAT inhibitor cyclosporin A prevents IH-induced hypertension. More importantly, NFATc3 knockout (KO) mice do not develop IH-induced hypertension. The goals of this... Elevated systemic TGF-{beta} impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE-/- mice The role of circulating, systemic TGF-β levels in endothelial function is not clear. TGF-β1 may cause endothelial dysfunction in apolipoprotein E-deficient (apoE–/–) mice via stimulation of reactive oxygen species (ROS) production by the NADPH oxidase (NOX) system and aggravate aortic and heart remodeling and hypertension. Thoracic aorta (TA) were isolated from 4-mo-old control (C57Bl/6), apoE–/–, TGF-β1-overexpressing (TGFβ1), and crossbred apoE–/– x TGFβ1 mice. Endothelium-dependent relaxation was measured before and after incubation with apocynin (NOX inhibitor) or superoxide dismutase (SOD; ROS scavenger). Superoxide production within the vessel wall was determined by dihydroethidine staining under confocal microscope. In 8-m... Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex Following sinoaortic denervation, which eliminates arterial baroreceptor input into the brain, there are slowly developing adaptations that abolish initial sympathetic activation and hypertension. In comparison, electrical stimulation of the carotid sinus for 1 wk produces sustained reductions in sympathetic activity and arterial pressure. However, whether compensations occur subsequently to diminish these responses is unclear. Therefore, we determined whether there are important central and/or peripheral adaptations that diminish the sympathoinhibitory and blood pressure-lowering effects of more sustained carotid sinus stimulation. To this end, we measured whole body plasma norepinephrine spillover and 1-adrenergic vascular reactivity in six dogs over a 3-wk period of baroreflex activatio...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway An increase in plasma ANG II causes neuronal activation in hypothalamic nuclei and a slow pressor response, presumably by increasing sympathetic drive. We evaluated whether the activation of a neuromodulatory pathway, involving aldosterone and "ouabain," is involved in these responses. In Wistar rats, the subcutaneous infusion of ANG II at 150 and 500 ng·kg–1·min–1 gradually increased blood pressure up to 60 mmHg at the highest dose. ANG II at 500 ng·kg–1·min–1 increased plasma ANG II by 4-fold, plasma aldosterone by 25-fold, and hypothalamic aldosterone by 3-fold. The intracerebroventricular infusion of an aldosterone synthase (AS) inhibitor prevented the ANG II-induced increase in hypothalamic aldosterone without affecting the increase ... Ethnic differences in resistance artery contractility of normotensive pregnant women Black women are at a greater risk to develop hypertension during pregnancy, with a 4.5 times higher rate of fatal preeclampsia than white women. Therefore, it is important to identify factors that may affect this risk. Our group previously proposed that high activity of the central regulatory enzyme of energy metabolism, creatine kinase (CK), may increase ATP-buffering capacity and lead to enhanced vascular contractility and reduced nitric oxide bioavailability. Therefore, we assessed microvascular contractility characteristics in isolated resistance arteries from self-defined black and white normotensive pregnant women using a Mulvany-Halpern myograph. Additionally, morphology was assessed with electron microscopy. Resistance-sized arteries obtained from omentum donated during cesarean se... The importance of elastin to aortic development in mice Elastin is an essential component of vertebrate arteries that provides elasticity and stores energy during the cardiac cycle. Elastin production in the arterial wall begins midgestation but increases rapidly during the last third of human and mouse development, just as blood pressure and cardiac output increase sharply. The aim of this study is to characterize the structure, hemodynamics, and mechanics of developing arteries with reduced elastin levels and determine the critical time period where elastin is required in the vertebrate cardiovascular system. Mice that lack elastin (Eln–/–) or have approximately one-half the normal level (Eln+/–) show relatively normal cardiovascular development up to embryonic day (E) 18 as assessed by arterial morphology, left ventricular ... Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats In conclusion, these results demonstrate that cardiac OTRs are involved in the regulation of cardiac function of OVX SHRs. The decreases of OTRs may contribute to cardiac pathology following menopause. (Source: AJP: Heart and Circulatory Physiology) Ultrasound-detected subchorionic hemorrhage and the obstetric implications. CONCLUSION:: Women with ultrasound-detected subchorionic hemorrhage before 22 weeks of gestation are at increased risk of placental abruption and preterm delivery but are not at increased risk of other adverse pregnancy outcomes. LEVEL OF EVIDENCE:: II. PMID: 20664390 [PubMed - in process] (Source: Obstetrics and Gynecology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Chorionic villus sampling at 11 to 13 weeks of gestation and hypertensive disorders in pregnancy. CONCLUSION:: There is no association between performing a CVS in the first trimester and subsequent development of hypertensive disorders of pregnancy. LEVEL OF EVIDENCE:: II. PMID: 20664398 [PubMed - in process] (Source: Obstetrics and Gynecology) Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy: A Meta-Analysis. CONCLUSION:: Low-dose aspirin initiated in early pregnancy is an efficient method of reducing the incidence of preeclampsia and IUGR. PMID: 20664402 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology) E-mail could be good for your patients? health Source: Pamela Lewis Dolan, amednews Content: “There is a strong link between patients’ ability to e-mail physicians and improved patient outcomes, concludes a study conducted by Kaiser Permanente. Kaiser retrospectively observed 35,423 patients with diabetes, hypertension or both in its Southern California region from February 2005 to December 2008. It found that within any two-month period, [...] (Source: ICMCC: The International Council on Medical and Care Compunetics) Dabigatran etexilate in people with atrial fibrillation (Source: BMJ Online First) Neighbourhood chronic stress and gender inequalities in hypertension among Canadian adults: a multilevel analysis Conclusions Although future research is needed to determine whether interventions at the area-level are effective in reducing inequalities in health outcomes across neighbourhoods, policies aimed at reducing area-level deprivation may have a differential benefit on the cardiovascular health of men and women. (Source: Journal of Epidemiology and Community Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Antenatal screening and predicting hypertension in pregnancy for midwives Conclusions: Further research should be focused on the factors observed by midwives during history taking and the antenatal course in the second and third trimesters and whether or not these can be synthesised in to a hypertension-specific diagnostic tool for use in midwifery practice. (Source: Women and Birth) Role of GABA(B) Receptors in Autonomic Control of Systemic Blood Pressure. Authors: Li DP, Pan HL GABA(B) receptors belong to family III G protein-coupled receptors (GPCRs) and are widely distributed in the peripheral and central nervous systems. The GABA(B) receptor is one of the most important therapeutic targets in the treatment for spasticity. GABA(B) agonists, such as baclofen, are used as muscle relaxants clinically and are effective for the treatment of anxiety, depression, epilepsy, and cognitive disorders (Caddick & Hosford, 1996; Dichter, 1997; Enna & Bowery, 1997). In addition, GABA(B) receptors regulate neurotransmitter release and neuronal excitability in the brain regions involved in the autonomic nervous system. Recent studies have led to a better understanding of the role of GABA(B) in the regulation of the autonomic nervous system, es... Pharmaceutical drug contamination of waterways threatens life on our planet This study was the first national-scale evaluation of pharmaceutical drug contamination in streams, and roughly 80 percent of the streams tested were found to be contaminated as well.In 2008, an AP investigation found that at least 46 million Americans are drinking water contaminated with trace amounts of pharmaceuticals. Even though every city tested has its water treated and "purified" prior to being delivered to the public, trace amounts of pharmaceutical drugs are making their way through to the tap. (Since not all major metropolitan areas were tested, the number of people affected is likely far higher than what was reported by AP.)In spite of all this, water quality reports don't disclose the levels of pharmaceuticals found in tap water. Since the EPA and FDA have failed to establish ... Comparison of the efficacy and tolerability of telmisartan and enalapril in patients of mild to moderate essential hypertension Conclusion : Telmisartan produces a greater reduction in diastolic BP than enalapril and is free from the adverse-effect of dry cough that is commonly encountered with enalapril. (Source: Indian Journal of Pharmacology) Nocturnal Nondipping and Left Ventricular Hypertrophy in Hypertension: An Updated Review The circadian rise and fall of blood pressure may have important links to cardiovascular diseases. Expert Review of Cardiovascular Therapy (Source: Medscape Cardiology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Middle Aortic Syndrome: Percutaneous Treatment With a Balloon-Expandable Covered Stent A 46-year-old female patient was admitted with signs of lower limb ischemia. Her examination demonstrated a nonpalpable distal pulse. Computed tomography angiography revealed an anomalous origin of both renal arteries (A, B) and severe aortic narrowing between the renal arteries, confirmed by the angiogram (C). The diagnosis was middle aortic syndrome (). Endovascular treatment was decided on, and a balloon-expandable covered stent (Jomed, Abbott Laboratories, Abbott Park, Illinois) was placed, with good stent expansion (D). Physical examination revealed distal pulse recovery. At 5 months, the patient remains asymptomatic. Computed tomography angiography showed stent patency (E, F). Middle aortic syndrome refers to an isolated disease of the thoracoabdominal aorta causing segmental narrowi... Oncology (Source: BMJ Online First) Risk factors associated with urinary albumin excretion in African Americans Authors: K E Ussai, S W Keith, E Pequignot & B Falkner (Source: Journal of Human Hypertension) Blood pressure elevation drives microalbuminuria Authors: B J Materson & S Chandra (Source: Journal of Human Hypertension) Review: Management of diabetes during Ramadan This article in 'Diabetes Care' on the management of diabetes during Ramadan addresses the following topics:   . Pathophysiology of fasting   . Risks associated with fasting in patients with diabetes: hypoglycaemia, hyperglycaemia, diabetic ketoacidosis, dehydration and thrombosis   . Management: frequent monitoring of glycaemia, nutrition, exercise, breaking the fast, pre-Ramadan medical assessment, Ramadan-focused structured diabetes education   . Management of patients with type 1 and type 2 diabetes   . Management of diet-controlled patients   . Diabetic medication adjustment during Ramadan   . Pregnancy and fasting during Ramadan   . Management of hypertension and dyslipidae...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Thromboxane Synthase Inhibitors and Thromboxane A(2) Receptor Antagonists: A Quantitative Structure Activity Relationships (QSARs) Analysis. Authors: Kontogiorgis C, Hadjipavlou-Litina D Thromboxane A(2) (TxA(2)), a bioactive metabolite of the Arachidonic acid (AA), is a potent mediator of platelet aggregation, vasoconstriction and bronchoconstriction. It plays an important role in major human diseases, such as myocardial infraction, unstable angina, pregnancy-induced hypertension and preeclampsia, thrombosis and thrombotic disorders, pulmonary hypertension, asthma, septic shock, atherosclerosis, lupus nephritis, and Raynaud's phenomenon. Thus, TxA(2) is a therapeutic target for many research groups. A number of TXA(2) receptor antagonists as well as thromboxane synthase inhibitors have been developed. In this research we review and evaluate new quantitative structure activity relationships of thromboxane synthase inhibitor... Leptin Plasma Levels in the General Population: Influence of Age, Gender, Body Weight and Medical History. Authors: Fulda S, Linseisen J, Wolfram G, Himmerich S, Gedrich K, PollmÃ¤cher T, Himmerich H The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in men, the association of leptin levels and age in women is an issue of scientific discussion. To investigate the association of age, gender, body mass index (BMI) and selected diseases with plasma levels of leptin in 551 adults randomly chosen from the Bavarian population, we assessed subjects' characteristics, lifestyle, and medical history including life time history of frequent ... Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones?Role of Age and Comorbid Diseases Author Summary Chronic kidney disease (CKD) is a common condition that is associated with substantial morbidity and mortality and has been recognized as a major public health problem worldwide. Common causes of CKD include hypertension, diabetes, and inflammatory disorders. Previous studies have shown a significant genetic contribution to kidney disease and a recent genome-wide association study yielded a variant in the UMOD gene that affects the risk of CKD. Here, we replicate the association between UMOD and CKD in an independent analysis. We also demonstrate for the first time an interaction between the UMOD variant and age that suggests that this variant may adversely affect the aging kidney and its adaptation to age-related risk factors of kidney disease, such as hypertension and dia... Salty Foods May Be Worse for You Than You Realize There are few out there who can resist indulging in salty foods now and again, whether their weakness is french fries, potato chips, movie popcorn or a bloody Mary. While having these foods every once in awhile isn’t a big deal health wise, it’s the salt that lurks in expected places that might be hurting you most. Many people don’t realize just how much sodium is in many of the foods they eat, and just what kind of negative effects it may be having on their bodies. The average adult shouldn’t consume more than 2400 mg of sodium a day, but many may be doing so quite unaware of how much salt is really in their food. Take canned soups for instance. Many are seemingly healthy, touting low calories and fat but masking an incredibly high amount of sodium (after all, they... Electronic Records May Help Improve BP Control Source: John Schieszer, Renal And Urology News Content: “New findings suggest that electronic health records (EHR) with special features for managing hypertension may be highly beneficial in improving BP control. Numerous approaches have been employed to improve BP control, including increasing patient involvement, improving patient compliance, reversing physician inertia, improving lifestyle modifications, and optimizing pharmacologic therapy. [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Are Primary Care Providers Uncomfortable Providing Routine Preventive Care for Inflammatory Bowel Disease Patients? Conclusions  Our study suggests that family medicine practitioners often do not feel comfortable providing care to IBD patients. Lack of familiarity with IBD medications may be a key factor. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1329-8Authors Lisbeth Selby, University of Kentucky Medical Center Department of Internal Medicine, Division of Digestive Diseases and Nutrition MN 649 Lexington KY 40536 USAAndrew Hoellein, University of Kentucky Medical Center Department of Internal Medicine, Division of General Internal Medicine K509 Kentucky Clinic Lexington KY 40536-0284 USAJohn F. Wilson, University of Kentucky Department of Behavioral Science 123 College of Medicine Office Building Lexington KY 40536-0086 USA Journal Digestiv... Soft Endpoint Sought for Pediatric PAH Trial (MedPage Today) -- An FDA advisory panel will revisit an increasingly familiar battleground this week, as it considers whether a drug sponsor can substitute a surrogate endpoint for a clinical outcome in a pediatric pulmonary arterial hypertension (PAH) trial. (Source: MedPage Today Public Health) The Role of Cellular Micronutrient Analysis, Nutraceuticals, Vitamins, Antioxidants and Minerals in the Prevention and Treatment of Hypertension and Cardiovascular Disease Diagnosis and treatment of nutrient deficiencies may reduce blood pressure and reduce cardiovascular events. Therapeutic Advances in Cardiovascular Disease (Source: Medscape Nephrology Headlines) New weight advice for pregnancy Many newspapers have reported on new official guidelines for how women can manage their weight before, during and after pregnancy. The advice comes from the National Institute for Health and Clinical Excellence (NICE). The importance of the guidelines are borne out by figures suggesting that more mothers than ever are overweight. The Guardian suggests that, ?15-20% of women getting pregnant are overweight or obese?. The Daily Mail puts the number higher, saying that ?almost half of expectant mothers are overweight or obese?. It goes on to spell out the dangers of being obese or overweight during pregnancy, which include ?fatal health conditions such as blood clots, pre-eclampsia, miscarriages and stillbirths?. The newspapers also dispel the myth that women should eat for two du... Researchers Identify Risks Of Hypertension In Young Adults Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls. According to the study published in Hypertension: Journal of the American Heart Association, the research team assessed how teenage boys and girls with normal blood pressure might progress into becoming young adults with hypertension... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> FDA Approves Tribenzor?, A New Three-In-One Combination Product For The Treatment Of High Blood Pressure Daiichi Sankyo, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved TRIBENZOR? (olmesartan medoxomil, amlodipine, hydrochlorothiazide), a new three-in-one combination product taken once-daily for the treatment of hypertension in patients who are not adequately controlled on any two of the following antihypertensive[1] drug classes: angiotensin receptor blockers, calcium channel blockers and diuretics. TRIBENZOR is not indicated for initial therapy... (Source: Health News from Medical News Today) PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways Peroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress. In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium. New functions of PPARs are reported in the arrhythmogenic right ventricular cardiomyopathy, a human genetic heart disease. It is now possible to link the genetic desmosomal abnormalitiy to the presence of fat in the right ventricle, partly due to an overexpression of PPARγ. Moreover, PPARs are... Increased Pulmonary Pressures and Myocardial Wall Stress in Children with Severe Malaria Conclusion.?Children with severe malaria have increased pulmonary pressures and myocardial wall stress. These complications are consistent with NO depletion from intravascular hemolysis, and they indicate that the pathophysiologic cascade from intravascular hemolysis to NO depletion and its cardiopulmonary effects is activated in children with severe malaria. (Source: The Journal of Infectious Diseases Latest Issue) Botulinum toxin-induced relaxation of the sphincter of Oddi may select patients with acalculous biliary pain who will benefit from cholecystectomy Conclusion  Botulinum toxin-induced relaxation of the SO may help to direct appropriate therapy for patients with acalculous biliary pain. The data from this study supports the establishment of a randomized clinical trial. Content Type Journal ArticleDOI 10.1007/s00464-010-1260-2Authors William R. Murray, Glasgow Royal Infirmary Lister Department of Surgery Glasgow G31 2ER Scotland UK Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy) Sarcoidosis-Associated Pulmonary Hypertension: Assessment and Management This article reviews the most recent data available in the epidemiology, pathophysiology, diagnosis, and treatment of SAPH.[...]© Thieme Medical PublishersGet connected:Table of contents \| Abstract \| Full text (Source: Seminars in Respiratory and Critical Care Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Health Insurance and Cardiovascular Disease Risk Factors Conclusion: The treatment and control of hypertension and hypercholesterolemia are lower among uninsured adults. Increasing the proportion of insured individuals may be a means to improve the treatment and control of cardiovascular disease risk factors and to reduce health disparities. (Source: The American Journal of Medicine) Prevalence and Characteristics of Tinnitus among US Adults Conclusions: The prevalence of frequent tinnitus is highest among older adults, non-Hispanic whites, former smokers, and adults with hypertension, hearing impairment, loud noise exposure, or generalized anxiety disorder. Prospective studies of risk factors for tinnitus are needed. (Source: The American Journal of Medicine) Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy Abstract: Background: Our understanding of the growing population of very old patients (aged ?80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes.Methods: This was a secondary analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable hypertensive coronary artery disease patients aged ?50 years. The patients were grouped by age in 10-year increments (aged ?80, n=2180; 70? (Source: The American Journal of Medicine) Impact Of Childhood Obesity Goes Beyond Health Adults who have been overweight since high school risk a lifetime of disease, discrimination and poverty. A new study of obese 40-year-olds found those who were overweight teens were three times more likely to suffer chronic health problems such as heart disease, diabetes and hypertension. They were also much more likely to be unemployed or receiving welfare.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science) Body mass index at age 17 within the normal range can predict future risk for hypertension in later life How might teenage boys and girls with normal blood pressure might progress into becoming young adults with hypertension? Boys are three to four times more likely to develop hypertension as young adults and the higher the blood pressure value, even within the normal range, the higher is the risk for becoming hypertensive adults, according to new research. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Adrenergic Signaling Polymorphisms and Their Impact on Cardiovascular Disease This review examines the impact of recent discoveries defining personal genetics of adrenergic signaling polymorphisms on scientific discovery and medical practice related to cardiovascular diseases. The adrenergic system is the major regulator of minute-by-minute cardiovascular function. Inhibition of adrenergic signaling with pharmacological β-adrenergic receptor antagonists (β-blockers) is first-line therapy for heart failure and hypertension. Advances in pharmacology, molecular biology, and genetics of adrenergic signaling pathways have brought us to the point where personal genetic differences in adrenergic signaling factors are being assessed as determinants of risk or progression of cardiovascular disease. For a few polymorphisms, functional data generated in cell-based sy... In vivo assessment of the hepatic microcirculation after mesenterico-portal bypass (REX-shunt) using orthogonal polarization spectral imaging This study investigates the hepatic microcirculation before and after REX-shunt interposition using orthogonal polarization spectral imaging (OPS). Since 2004, three consecutive patients with extrahepatic portal vein thrombosis underwent REX-shunt interposition. We measured the hepatic microcirculation by OPS before and directly after REX-shunt reperfusion and analysed the capillary vessel diameter, red blood cell velocity, functional capillary density and volumetric blood flow. Furthermore, we compared our values with the physiological values of the hepatic microcirculation defined previously by other investigators. All shunts showed an excellent function in the follow-up investigations. The intra-individual microcirculatory analysis revealed a reduction in the red blood cell velocity aft... CCGMP Pulmonary Disease Chapter 11 - Pulmonary Hypertension (Source: Modern Medicine) CCGMP Pulmonary Disease Chapter 11 - Pulmonary Hypertension (Source: Modern Medicine) Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats. Authors: Sabuhi R, Asghar M, Hussain T A positive association between renin angiotensin system, especially AT1 receptor and oxidative stress in the pathogenesis of hypertension and cardiovascular/renal diseases has been suggested. However, the role of oxidative stress, especially superoxide radicals in renal sodium handling in response to AT1 and AT2 receptors is not known. Therefore, the present study was designed to investigate the role of NAD(P)H oxidase (NOX), a major superoxide radical producing enzyme, in AT1 and AT2 receptor function on natriuresis/diuresis in SD rats. The rats under anesthesia were intravenously infused with NOX inhibitor apocynin (3.5 mug/kg/min), the AT1 receptor antagonist candesartan (100 mug/kg; bolus) and the AT2 receptor agonist CGP- 42112A (1 mug/kg/min...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in ren-2 transgenic rats. In conclusion, aliskiren and losartan had similar antihypertensive effects during chronic treatment, but the antihypertensive and organoprotective effects of aliskiren were persistent even after the 12-day washout period. The durable effect on proteinuria can possibly be attributed to the normalization of glomerular morphology. PMID: 20668096 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...) Moderate hyperbilirubinemia improves renal hemodynamics in angiotensin ii dependent hypertension. MODERATE HYPERBILIRUBINEMIA IMPROVES RENAL HEMODYNAMICS IN ANGIOTENSIN II DEPENDENT HYPERTENSION. Am J Physiol Regul Integr Comp Physiol. 2010 Jul 28; Authors: Vera T, Stec DE We have previously demonstrated that moderate hyperbilirubinemia decreases blood pressure in Angiotensin (Ang) II-dependent hypertension through mechanisms that decrease oxidative stress and increase nitric oxide levels. Since decreases in renal hemodynamics play an important role in mediating the hypertensive actions of Ang II, the goal of the present study was to examine the effect of moderate hyperbilirubinemia on glomerular filtration rate (GFR) and renal blood flow (RBF) in a mouse model of Ang II hypertension. Mice were made moderately hyperbilirubinemic by two methods: Indinavir or specific morphol... Efficacy of amiodarone on refractory ventricular fibrillation resistant to lidocaine and cardioversion during weaning from cardiopulmonary bypass in aortic valve replacement for severe aortic stenosis with left ventricular hypertrophy Abstract  Intravenous injection of amiodarone, a class III anti-arrhythmic is widely used for persistent refractory arrhythmias. We present a case report suggesting the efficacy of amiodarone in refractory ventricular fibrillation (Vf) during weaning from cardiopulmonary bypass (CPB). A 66-year-old woman with hypertension had a medical examination as a result of an episode of palpitations and syncope. Echocardiography and an invasive hemodynamic study revealed severe aortic stenosis (AS) with left ventricular (LV) hypertrophy because of calcified degeneration in a congenital bicuspid aortic valve (AV). Aortic valve replacement (AVR) was scheduled under general anesthesia and CPB. Intraoperative diagnosis was AS with calcified AV, LV hypertrophy, and aneurysm of ascending ao... Renal artery stenosis with significant proteinuria may be reversed after nephrectomy or revascularization in patients with the antiphospholipid antibody syndrome: a case series and review of the literature Abstract  Renal artery stenosis (RAS) is a disease which might present as hypertension, renal insufficiency or proteinuria and even as nephrotic syndrome. While 90% of cases are secondary to atherosclerosis, the rest of the cases are usually related to fibromuscular dysplasia. Recently, RAS has also been documented in patients with the antiphospholipid syndrome (APS). Although cases of nephrotic syndrome induced by RAS have been published, cases of patients with APS and nephrotic syndrome attributed to RAS were not reported in the literature. In this paper, three young male patients with APS, hypertension and significant proteinuria secondary to RAS are presented. The patients were treated with nephrectomy or revascularization in addition to prior treatment with warfarin, w... Smoking May Worsen Outcome of Pregnancy Complication A new study suggests that smokers who develop preeclampsia during pregnancy are at particular risk of suffering the complications associated with the disorder -- including preterm delivery, low birth weight and stillbirth.Source: Reuters Health Related MedlinePlus Pages: High Blood Pressure in Pregnancy, Pregnancy and Substance Abuse (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Prevalence and Diagnosis of Primary Aldosteronism Abstract  Primary aldosteronism (PA) is a common cause of arterial hypertension: in the PA Prevalence in Hypertensives (PAPY) Study, the prevalence of PA was 11.2% in consecutive referred hypertensive patients. When adrenal vein sampling (AVS) is available, two thirds of the cases can be attributed to a tumor and one third of cases are idiopathic; the opposite is seen when AVS is unavailable. Thus, AVS influences the relative prevalence rate of the main subtypes of PA. When adrenalectomy is undertaken based on AVS, almost 100% of patients are cured of hyperaldosteronism, one third are cured of hypertension, and 52% are markedly improved in terms of blood pressure control. Persistent hypertension can be predicted by a long history of hypertension and by the presence of exces... Surgical Approach for Aortic Coarctation Influences Arterial Compliance and Blood Pressure Control [ORIGINAL ARTICLES: PEDIATRIC CARDIAC] Conclusions Young children undergoing SFR have higher blood pressure and stiffer upper limb arteries compared with matched children undergoing EEA. Our data suggest that better longer-term cardiovascular outcome is to be expected with the EEA surgical approach. (Source: The Annals of Thoracic Surgery) Ben-Gurion University of the Negev Researchers Identify Risks of Hypertension in Young Adults July 27, 2010 (EurekAlert) - Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls. read more (Source: Diabetes News from dLife.com) Ben-Gurion University of the Negev Researchers Identify Risks of Hypertension in Young Adults July 27, 2010 (EurekAlert) - Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls. read more (Source: Diabetes News from dLife.com) Aliskiren Versus Ramipril in Hypertension Three studies are compared to evaluate the antihypertensive effects of these two monotherapies. Therapeutic Advances in Cardiovascular Disease (Source: Medscape Nephrology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> New proteins that regulate blood pressure, flow discovered Researchers have identified key players in a little-known biochemical pathway that appears to regulate blood pressure. The findings could lead to a better understanding of who will get high blood pressure and why, as well as allow us to develop better drugs to treat these patients. (Source: ScienceDaily Headlines) Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation Conclusion Common non-synonymous genetic variants within NPPA in these two large North American cohorts of European ancestry are not associated with the development of AF. (Source: Europace) FDA Alert - Vialipro Dietary Supplement Recalled: Undeclared Drug Ingredient The undeclared ingredient may pose a threat to the consumer because the interaction of the analogue with some prescription drugs (such as nitroglycerin) may lower blood pressure to dangerous levels. Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take other prescription drugs. (Source: NCCAM Featured Content) Mycophenolic acid in Rheumatology: mechanisms of action and severe adverse events. Authors: Zizzo G, De Santis M, Ferraccioli GF Mycophenolic acid (MPA) is an immunosuppressive agent, more and more extensively used in transplantation, rheumatology and nephrology. In this review, we will analyze the molecular mechanisms of its action, including the newest insights, in particular the inhibition of lymphocytes and the induction of tolerogenic dendritic cells (DCs) and its direct effects on non-immune cells (fibroblasts and myofibroblasts, mesangial cells, vascular smooth muscle cells [VSMC], endothelial cells). The latters suggest new therapeutic indications, specifically fibrosis (i.e. glomerulosclerosis and interstitial lung diseases), vascular damage and pulmonary hypertension, which represent key pathogenic features in connective tissue diseases. Given the differenc... First Nations People On Peritoneal Dialysis At Greater Risk Of Infection And Death First Nations people in Canada on peritoneal dialysis are at increased risk of peritonitis and death, irrespective of whether they live in a rural or urban location, found a study published in CMAJ (Canadian Medical Association Journal). The high prevalence of diabetes, obesity and hypertension in Canada's First Nations, or aboriginal, population is fuelling the rapid growth of kidney disease and renal failure and consequent need for care and dialysis. Peritonitis is inflammation of the peritoneum (the inner lining of the abdominal and pelvic walls), often caused by infection... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Scientists discover olive oil directly impacts genes to halt inflammation (NaturalNews) Research has been steadily accumulating that olive oil, a main component of the Mediterranean diet, has extensive health-protective properties. For example, phytonutrient components of olive oil have been found to be effective against breast cancer cells (http://www.naturalnews.com/025633_cancer_olive_oil_brst.html) and studies suggest the abundance of olive oil in the Mediterranean style of eating may be the reason that diet helps prevent depression (http://www.naturalnews.com/027265_depression_mediterranean_diet_health.html). Now scientists have discovered that phenolic compounds in olive oil directly repress genes linked to inflammation. This could be especially important in halting the dangerous effects of metabolic syndrome. Characterized by excess abdominal fat, high ch... CHMP Adopts Positive Opinion For TWYNSTA(R), Boehringer Ingelheim's New Single Pill Combination Hypertension Treatment Boehringer Ingelheim announced that the European Committee for Medicinal Products for Human Use (CHMP) adopted a Positive Opinion for the approval of TWYNSTA®. It will be indicated in adults whose blood pressure is not adequately controlled on amlodipine and is also indicated as replacement therapy in adult patients receiving telmisartan and amlodipine from separate tablets can instead receive tablets of TWYNSTA containing the same component doses... (Source: Health News from Medical News Today) amlodipine and valsartan (Exforge) Title: amlodipine and valsartan (Exforge)Category: MedicationsCreated: 7/27/2010 3:42:00 PMLast Editorial Review: 7/27/2010 3:42:20 PM (Source: MedicineNet High Blood Pressure General) Combination Drug Approved for High Blood Pressure Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet High Blood Pressure General) To Help Keep Weight Off, Turn to the Web Title: To Help Keep Weight Off, Turn to the WebCategory: Health NewsCreated: 7/27/2010 8:10:00 AMLast Editorial Review: 7/27/2010 (Source: MedicineNet High Blood Pressure General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Combination Drug Approved for High Blood Pressure Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Senior Health General) Combination Drug Approved for High Blood Pressure Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Migraine General) Combination Drug Approved for High Blood Pressure Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Digestion General) Ben-Gurion University of the Negev researchers identify risks of hypertension in young adults (American Associates, Ben-Gurion University of the Negev) According to the study published in Hypertension, the American Heart Association journal, the research team assessed how teenage boys and girls with normal blood pressure might progress into becoming young adults with hypertension. Currently, systolic blood pressures of 100 to 110 and even up to 120 are considered within the normal range for adolescents. Other traits like weight, height and body mass index have a range of distribution that is considered "normal." (Source: EurekAlert! - Social and Behavioral Science) A phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas The authors evaluated a 3-week schedule of bevacizumab in patients with recurrent high-grade glioma (HGG).Patients received bevacizumab 15 mg/kg every 3 weeks and were evaluated every 6 weeks until tumor progression. Tissue correlates were used to quantify tumor content of vascular endothelial growth factor A (VEGFA) and vascular endothelial growth factor receptor-2 (VEGFR2).Of 61 patients who were treated (35 men and 26 women; median age, 52 years; age range, 21-78 years), 50 patients had glioblastoma multiforme (GBM), and 11 patients had anaplastic glioma (AG). The median number of previous chemotherapies was 2 (range, 1-5 previous chemotherapies), and 16 patients had received [ge]3 previous chemotherapies. The median number of bevacizumab doses was 4 (range, 1-20 doses), and 45% of pati...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension Authors: S Francque, A Verrijken, I Mertens, G Hubens, E Van Marck, P Pelckmans, P Michielsen & L Van Gaal (Source: International Journal of Obesity) eNOS haplotype associated with hypertension in obese children and adolescents Authors: D C Souza-Costa, V A Belo, P S Silva, I F Metzger, C M Lanna, M A Machado & J E Tanus-Santos (Source: International Journal of Obesity) The possibility of microarray-based analysis using cell-free placental mRNA in maternal plasma The purpose of this study is to investigate a possibility of overall assessment of cell-free (CF) placental mRNAs in maternal plasma.First, placenta-predominantly expressed transcripts were selected by the analysis of GeneChip using three sets of placental tissues and corresponding maternal blood cells. Subsequently, a custom cDNA array panel of placenta-predominantly expressed transcripts was designed and used to compare the RNA profiles of maternal plasma collected from 12 preeclamptic and 12 uncomplicated pregnancies. Scatter plots for the signal intensities of the comparative cDNA hybridization revealed either unchanged or aberrant patterns.We selected top 50 placenta-predominantly expressed transcripts that were > 2500 times higher in placental tissues than in corresponding whole bloo... Detection and Treatment of Resistant Hypertension Abstract  The evaluation of patients with resistant hypertension should be directed toward confirming true treatment resistance, identifying the causes contributing to treatment resistance (including secondary causes of hypertension), and documenting target-organ damage. Treatment of resistant hypertension is aimed at reversing lifestyle factors contributing to treatment resistance, accurately diagnosing and appropriately treating secondary causes of hypertension, and effectively using multidrug regimens. Lifestyle changes, pharmacologic therapies, and nonpharmacologic therapies have all shown benefits in patients with resistant hypertension, but much additional knowledge is needed to better identify and treat these patients. Content Type Journal ArticleDOI 10.1007/s119... FDA Approves Another Triple-Drug Combination for Resistant Hypertension: Tribenzor The new product combines the angiotensin-receptor blocker olmesartan, the calcium-channel blocker amlodipine, and the diuretic hydrochlorothiazide. Heartwire (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> FDA Okays New Hypertension Polypill WASHINGTON (MedPage Today) -- The FDA has approved a combination of three hypertension drugs -- olmesartan medoxomil, amlodipine, and hydrochlorothiazide (Tribenzor) -- to treat patients whose blood pressure is not controlled on angiotensin receptor blockers, calcium channel blockers, or diuretics. (Source: MedPage Today Public Health) Combination Drug Approved for High Blood Pressure Tribenzor sanctioned for those who don't respond to other drugs (Source: The Doctors Lounge - Cardiology) FDA approves another triple-drug combination for resistant hypertension: Tribenzor The new product combines the angiotensin-receptor blocker olmesartan, the calcium-channel blocker amlodipine, and the diuretic hydrochlorothiazide. For complete story visit theheart.org. (Source: theHeart.org) Combination Drug Approved for High Blood Pressure Tribenzor sanctioned for those who don't respond to other drugsSource: HealthDay Related MedlinePlus Pages: Blood Pressure Medicines, High Blood Pressure (Source: MedlinePlus Health News) Imatinib Promising for Refractory Pulmonary Artery Hypertension The tyrosine kinase inhibitor (TKI) imatinib is a useful add-on treatment when pulmonary artery hypertension (PAH) hasn't responded to standard therapy, according to a European study. Reuters Health Information (Source: Medscape Medical News Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Daiichi nets FDA nod for 3-in-1 hypertension med The FDA has approved Daiichi Sankyo's olmesartan medoxomil/amlodipine/hydrochlorothiazide (Tribenzor), a three-in-one combination product taken once-daily for the treatment of hypertension in patients who are not adequately controlled on the following antihypertensive drug classes: angiotensin receptor blockers, calcium channel blockers and diuretics. (Source: Cardiovascular Business News) FDA Approves Tribenzor, A New Three-In-One Combination Product for the Treatment of High Blood Pressure One in Three US Adults Have Hypertension and Many Are Uncontrolled on Two or More Antihypertensive Medications(1) PARSIPPANY, N.J., July 26 (HSMN NewsFeed) -- Daiichi Sankyo, Inc. announced today that the U.S. Food and Drug Administration (FDA) approv... Biopharmaceuticals, FDADaiichi Sankyo, TRIBENZOR, hypertension (Source: HSMN NewsFeed) FDA Approves Tribenzor, A New Three-In-One Combination Product for the Treatment of High Blood Pressure PARSIPPANY, N.J., July 26 /PRNewswire/ -- Daiichi Sankyo, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide), a new three-in-one combination product... (Source: Drugs.com - New Drug Approvals) IVF death risk 'overstated' Conclusion This cross-sectional study determined the rate of deaths due to IVF treatment or pregnancies in the Netherlands between 1984 and 2008. The Daily Telegraph?s headline and report are potentially misleading. The news article focuses primarily on the increased risk of women?s bodies rejecting donated eggs or underlying health problems coming to the fore. However, it is a fact that women who have IVF tend to be older, and are therefore at greater risk of having adverse outcomes. Also, the report that risk of death is three times higher than natural conceptions fails to mention that the actual number of women who died of potential IVF related problems in this study remained relatively low, at only 43 for every 100,000 women who had IVF. There are a number of important points to co... Prolonged infusions of dexmedetomidine in critically ill patients. Conclusion Dexmedetomidine is an alternative to traditional sedatives and analgesics in critically ill patients. The safety and efficacy of dexmedetomidine in adults likely persist beyond 24 hours, without the emergence of rebound effects after discontinuation. PMID: 20651314 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Great Tastes And International Recipes That Reduce The Risk Of Heart Disease The European Society of Cardiology (ESC) has announced the upcoming launch of its all-new European Cook Book. Bringing together recipes created by leading cardiologists from across its membership, the aim of this high quality book is to demonstrate that a diverse, heart-friendly diet can be achieved without compromising on taste. The ESC strongly endorses a healthy and balanced diet as an effective means of lowering the risks from conditions such as hypertension, diabetes and coronary artery disease... (Source: Health News from Medical News Today) As Weight Goes Up, So Do Heart Risks Title: As Weight Goes Up, So Do Heart RisksCategory: Health NewsCreated: 7/23/2010 12:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet High Blood Pressure General) Shedding Pounds Saved One Woman's Life Title: Shedding Pounds Saved One Woman's LifeCategory: Health NewsCreated: 7/23/2010 12:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet High Blood Pressure General) Relationship Insecurity May Undermine Your Health Title: Relationship Insecurity May Undermine Your HealthCategory: Health NewsCreated: 7/24/2010 8:10:00 AMLast Editorial Review: 7/26/2010 (Source: MedicineNet High Blood Pressure General) EU committee recommends Boehringer's hypertension drug for approval The European Committee for Medicinal Products for Human Use has adopted a Positive Opinion for the approval of Boehringer Ingelheim?s single pill combination hypertension drug telmisartan/amlodipine (Twynsta). (Source: Cardiovascular Business News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> No harm from relaxed antihypertensive strategy in acute stroke Stopping pre-existing antihypertensive treatment for 2 weeks after an acute stroke does not appear to harm patients, show the results of the COSSACS trial. (Source: MedWire News - Hypertension) Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu Background: Obesity is a pro-inflammatory state frequently associated with widespread metabolic alterations that include insulin resistance and deregulation of blood pressure (BP). This cascade of events in some measure explains the susceptibility of obese adults for co-morbid conditions like diabetes mellitus and hypertension.Hypothesis: We hypothesized that an elevated systemic proinflammatory burden correlates with dysglycemia and deregulated blood pressure. Methods: We analyzed the screening anthropometric and laboratory measures from healthy disease free obese adults (n=35; women (W) 27, men (M) 8) in a weight loss study. Results: Healthy obese normoglycemic (fasting serum glucose: FSG (Source: Journal of Inflammation) CHMP recommends EU approval of combination telmisartan/amlodipine product (Twynsta®) Source: European Medicines Agency (EMA) Area: News The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended that the combination product Twynsta® (telmisartan/amlodipine) be given a marketing authorisation for the treatment of essential hypertension. (Source: NeLM - News) Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course. Longitudinal Observations From the Framingham Heart Study. Conclusions-Cardiac remodeling over the adult life course is characterized by a distinct pattern of increasing LV wall thickness, decreasing LV dimensions, and increasing fractional shortening with advancing age. Overall, female sex, greater blood pressure load, and presence of diabetes mellitus serve to attenuate this remodeling pattern. These observations suggest a mechanism for the preponderance of women with hypertension and individuals with diabetes among patients with diastolic heart failure. PMID: 20660804 [PubMed - as supplied by publisher] (Source: Circulation) Hypertension in Pregnancy and Later Cardiovascular Risk. Common Antecedents? Conclusions-These results suggest that the positive association of preeclampsia and gestational hypertension with postpregnancy cardiovascular risk factors may be due largely to shared prepregnancy risk factors rather than reflecting a direct influence of the hypertensive disorder in pregnancy. PMID: 20660802 [PubMed - as supplied by publisher] (Source: Circulation)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Time to abandon small-sample cohort research in health psychology? Comments on the original article, "Avoidant coping as a predictor of mortality in veterans with end-stage renal disease" by E. J. Wolf and D. L. Mori (see record 2009-06704-009), in which the authors report that among 61 patients with endstage renal disease (ESRD), avoidant coping more than doubled the odds of mortality in multivariable analysis. The authors concluded that evaluating coping style in patients with ESRD would be clinically useful and that interventions targeting avoidant coping should be investigated. In this commentary, the current authors note that Wolf and Mori?s (2009) finding was based on a sample where only 23 patients died over 9 years, and results were evaluated using a Cox regression model with six covariates, a ratio of only 3.8 outcome events per variable?well... Associations between adult attachment ratings and health conditions: Evidence from the National Comorbidity Survey Replication. Conclusion: The findings were generally supportive of the theory that insecure attachment is a risk factor for the development of disease and chronic illness, particularly conditions involving the cardiovascular system. Further research regarding the role of attachment in the development of specific health conditions is warranted. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (Source: Health Psychology) Relationship Insecurity May Undermine Your Health People who feel anxious and needy at higher risk of heart disease, high blood pressure, chronic pain and stroke, researchers findSource: HealthDay Related MedlinePlus Pages: Heart Diseases, Mental Health (Source: MedlinePlus Health News) Applying Ontology Techniques to Develop a Medication History Search and Alert System in Department of Nuclear Medicine Source: Chen J et al, Journal of Medical Systems, 2010 Content: Nowadays, patients usually take more than three drugs for diseases such as hypertension, diabetes, and dyslipidemia. Hence, nuclear medicine physicians should be very careful about the medication history of each patient and ensure that their medication will not cause false positive or false negative [...] (Source: ICMCC: The International Council on Medical and Care Compunetics) Effect of an Olmesartan Medoxomil-Based Treatment Algorithm on Systolic Blood Pressure in Patients with Stage 1 or 2 Hypertension: A Randomized, Double-Blind, Placebo-Controlled Study (Source: American Journal of Cardiovascular Drugs)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Trends for type 2 diabetes and other cardiovascular risk factors in Mexico from 1993-2006. CONCLUSIONS: This increasing trends for the prevalence of T2D and cardiovascular risk factors predicts larger increments in the near future for T2D and cardiovascular morbidity and mortality. Intensification of the preventive and remedy strategies is mandatory in order curve the foreseen dramatic increment in the disease burden. PMID: 20585732 [PubMed - in process] (Source: Salud Publica de Mexico) Hypertension in Mexican adults: results from the National Health and Nutrition Survey 2006. CONCLUSIONS: Hypertension is one of the most prevalent chronic diseases in Mexico. In the last six years in Mexico, a substantial increase (25%) has been observed in contrast to the reduction seen among Mexican-Americans (-15%). PMID: 20585731 [PubMed - in process] (Source: Salud Publica de Mexico) Methodology for the analysis of type 2 diabetes, metabolic syndrome and cardiovascular disease risk indicators in the ENSANUT 2006. CONCLUSIONS: The randomly selected sub-sample was not essentially different from the rest of the fasting subjects. Thus, no bias is expected in the interpretation of cardiovascular risk indicators derived from these data. PMID: 20585728 [PubMed - in process] (Source: Salud Publica de Mexico) Significance of serum uric acid in pulmonary hypertension due to systemic sclerosis: a pilot study Abstract  Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to investigate the potent relationship between serum UA and pulmonary pressure as well as functional capacity in patients with SSc. We studied 66 patients (mean age 57.7 ± 12.1 years, 63 women), presenting with SSc. Systolic pulmonary artery pressure assessed by echocardiography, lung function tests, six-minute walk test (6MWT) and serum UA levels were recorded in all patients. In 24 (36%) patients, the diagnosis of PH was established by echoca... Comparing self-reported and measured high blood pressure and high cholesterol status using data from a large representative cohort study. Conclusion: Although self-reported measures are consistent over time there are major differences between the self-reported measures and the actual clinical measurements. Technical aspects associated with clinic measurements could explain some of the difference. Implications: Monitoring of these broad population measures requires knowledge of the differences and limitations in population settings. PMID: 20649780 [PubMed - in process] (Source: Australian and New Zealand Journal of Public Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Usefulness of multi-detector helical CT with multiplanar reconstruction for depicting the duodenal varices with multiple collateral shunt vessels We report the case of a 58-year-old man with liver cirrhosis with repeated bleeding from duodenal varices. Esophagogastroduodenoscopy (EGD) revealed multinodular varices in the third portion of the duodenum. Then we conducted a capsule endoscopy (CE) and found fresh blood in the duodenum, suggesting duodenal variceal hemorrhage. Angiography depicted the varices with one afferent and two efferent vessels. Abdominal CT examination was conducted using a four-channel multi-detector row CT scanner. The multiplanar reconstructed images revealed not only the varices, but also three afferent and two efferent vessels. The patient was treated by surgical ligation and sclerotherapy, because of its complicated porto-systemic shunt and reserved liver function. No gastrointestinal bleeding has bee... Renal involvement in childhood-onset systemic lupus erythematosus in Egypt This study aims to characterize the features and outcome of renal involvement in childhood-onset SLE based on a study of 100 Egyptian patients (mean age at diagnosis 10.1 years, range 2?17 years). Initial data regarding disease manifestations and biopsy findings were reviewed. Disease activity was assessed using SLEDAI scores. Follow-up data (mean duration 6 years) were noted regarding specific treatment, response, complications and renal survival. Initial renal involvement was present in 78 patients, including 66 with hypertension and 23 with renal impairment. Pathologically, class IV nephropathy was found in 18 patients, class V in 9 and low-grade lesions (class II?III) in 49. Twenty patients required follow-up biopsy, and all transformations were observed. SLEDA... Secondary Ocular Hypertension After Intravitreal Injection with 2?mg or 4?mg of Triamcinolone in Retinal Vein Occlusion Journal of Ocular Pharmacology and Therapeutics , Vol. 0, No. 0. (Source: Journal of Ocular Pharmacology and Therapeutics) Association of dietary nutrient intakes in relation to progression of diabetic retinopathy in blacks with type I diabetes mellitus The leading cause of blindness in diabetic people ages 20 to 64 years in the United States is complications of diabetic retinopathy (DR). Risk factors, including the duration of the disease, poor glycemic control, and systemic hypertension, have all been linked to progression of retinopathy. The American Diabetic Association (ADA) recommends restricting carbohydrate and fat intake for all patients with diabetes and restricting sodium intake for diabetic patients with hypertension. The investigators of the study evaluated the association of dietary nutrient intakes in relation to the 6-year progression of DR in blacks with type 1 diabetes mellitus. (Source: Optometry - Journal of the American Optometric Association) Glomerular filtration rate measured by 51Cr-EDTA clearance: evaluation of captopril-induced changes in hypertensive patients with and without renal artery stenosis CONCLUSIONS: Captopril induced a decrease in the GFR that could be quantitatively measured with 51Cr-EDTA. The reduction is more pronounced in hypertensive patients with RAS. (Source: Clinics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA. (Source: Brazilian Oral Research) Lipins: multifunctional lipid metabolism proteins. Authors: Csaki LS, Reue K The lipin proteins are evolutionarily conserved proteins with roles in lipid metabolism and disease. There are three lipin protein family members in mammals and one or two orthologs in plants, invertebrates, and single-celled eukaryotes. Studies in yeast and mouse led to the identification of two distinct molecular functions of lipin proteins. Lipin proteins have phosphatidate phosphatase activity and catalyze the formation of diacylglycerol in the glycerol-3-phosphate pathway, implicating them in the regulation of triglyceride and phospholipid biosynthesis. Mammalian lipin proteins also possess transcriptional coactivator activity and have been implicated in the regulation of metabolic gene expression. Here we review key findings in the field that demonstrate... The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic Fatty liver disease associated with the metabolic syndrome. Authors: Jornayvaz FO, Samuel VT, Shulman GI The metabolic syndrome is a clustering of cardiovascular risk factors, including insulin resistance, abdominal obesity, dyslipidemia, and hypertension, and is associated with other comorbidities such as a proinflammatory state and nonalcoholic fatty liver disease (NAFLD). Its prevalence is high, especially among developed countries, and mainly reflects overnutrition and sedentary lifestyle. Moreover, the developing countries are not spared, as obesity and its related problems such as the metabolic syndrome are increasing quickly. We review the potential primary role of skeletal muscle insulin resistance in the pathophysiology of the metabolic syndrome, showing that in lean, young, insulin-resistant individuals, impaired muscle glucose transp... The effect of nutrition on blood pressure. Authors: Savica V, Bellinghieri G, Kopple JD The incidence and severity of hypertension are affected by nutritional status and intake of many nutrients. Excessive energy intake and obesity are major causes of hypertension. Obesity is associated with increased activity of the renin-angiotensin-aldosterone and sympathetic nervous systems, possibly other mineralcorticoid activity, insulin resistance, salt-sensitive hypertension and excess salt intake, and reduced kidney function. High sodium chloride intake strongly predisposes to hypertension. Increased alcohol consumption may acutely elevate blood pressure. High intakes of potassium, polyunsaturated fatty acids, and protein, along with exercise and possibly vitamin D, may reduce blood pressure. Less-conclusive studies suggest that amino... Dialysis More Likely than Death in Blacks (CME/CE) African Americans with hypertension-associated kidney disease were more likely to develop end-stage renal disease (ESRD) than to die, researchers conducting a long-term cohort study said. (Source: MedPage Today Nephrology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Relationship Insecurity May Undermine Your Health People who feel anxious and needy at higher risk of heart disease, high blood pressure, chronic pain and stroke, researchers find (Source: The Doctors Lounge - Cardiology) First case of childhood Takayasu arteritis with renal artery aneurysms We report a 12-year-old boy with Takayasu arteritis who developed severe hypertension, proteinuria, microscopic hematuria and renal dysfunction. Conventional angiography demonstrated aneurysms of both renal arteries and multiple microaneurysms of the superior mesenteric artery. This case report illustrates that the children with Takayasu arteritis can develop renal involvement resulting in hematuria, proteinuria and even renal failure. (Source: BioMed Central) Unfavourable trends in cardiovascular and metabolic risk in paediatric and adult patients with congenital adrenal hyperplasia? Conclusions Our findings suggest that adult CAH patients tend to have a cluster of metabolic risk factors, which are consistent with the metabolic syndrome. This notion may have consequences for the care for this group of patients. (Source: Clinical Endocrinology) A Rare Cause of Recurrent Hematuria in Children: Nutcracker Syndrome We report a 6-year-old girl with episodic macroscopic hematuria who was diagnosed as NCS with Doppler ultrasound and 3D computerized tomography angiography. She was managed conservatively with spontaneous resolution of macroscopic hematuria. With this case we would like to emphasize that in children with hematuria and orthostatic proteinuria without an apparent cause, a great index of suspicion and appropriate imaging is necessary for the diagnosis of NCS. (Source: Journal of Tropical Pediatrics)

hypertension and high blood pressure guide

Understanding Hypertension And High Blood Pressure

Hypertension is most commonly referred to as having "high blood pressure", HTN or HPN, is a medical condition in which the blood pressure is chronically elevated. High blood pressure is considered to be present when a person's systolic blood pressure is consistently 140 mmHg or greater, and/or their diastolic blood pressure is consistently 90 mmHg or greater.

Hypertension, or high blood pressure, is a condition that affects many people in this country. However, many of these people are not even aware of their condition, since high blood pressure often has few if any symptoms. Undiagnosed hypertension can elevate the risk of many other health conditions, such as heart disease and stroke. The good news is that high blood pressure is fairly easy to diagnose when it is tested for regularly, and there are many options in treating this condition that include lifestyle changes and medication.

Hypertension Risk Factors

Over the early years of life and into middle age, men tend to be more likely to be diagnosed with high blood pressure. In the later years, after menopause, the statistics for women and menopause tend to go up as well. Race is another risk factor in hypertension, with African Americans much more likely to be diagnosed with this condition than whites, and usually at an earlier age.

Other types of risk

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Description of the feeding dynamics of institutionalized elderly women
CONCLUSION: Environmental, cognitive and behavioral factors related to feeding were significantly present among the subjects of the study, putting deglutition at risk. Other specific deglutition difficulties were also identified. Managing these difficulties is important, in order to avoid health complications for elderly women. (Source: Revista da Sociedade Brasileira de Fonoaudiologia)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Sleep Duration and Cardiovascular Disease: Results from the National Health Interview Survey
Conclusion: Compared with sleep duration of 7 h, there was a positive association between both shorter and longer sleep durations and CVD in a representative sample of US adults. These results suggest that sleep duration may be an important marker of CVD. Keywords: Sleep, sleep duration, cardiovascular disease, NHIS (Source: Sleep)
The Effects of Sleep-Disordered Breathing on Arterial Stiffness are Modulated by Age
Conclusions: Adverse effects of nocturnal oxygen desaturation on PWV are seen among normotensive individuals and are amplified with aging. Integrated assessment of SDB is necessary to characterize its effects on arterial stiffness. Keywords: Arteries, hypertension, sleep apnea, vascular disease (Source: Sleep)
Mechanisms underlying uremic encephalopathy
Em pacientes com insuficiência renal, a encefalopatia é um problema comum que pode ser provocado pela uremia, deficiência de tiamina, diálise, rejeição de transplante, hipertensão, desequilíbrios hidroeletrolíticos e toxicidades medicamentosas. Em geral a encefalopatia se apresenta como um complexo de sintomas que progride de uma leve obnubilação sensitiva até delírio e coma. Esta revisão discute questões importantes com relação aos mecanismos de base da fisiopatologia da encefalopatia urêmica. A fisiopatologia da encefalopatia urêmica é até hoje incerta, mas postula-se o envolvimento de diversos fatores; trata-se de um processo complexo e provavelmente multifatorial. Distúrbios hormonais, estresse oxidativo, acúmulo de metabólitos, desequilíbrio entre os neurotran...
Woman saves her own life by losing 200 pounds
Marci Williams, at 332 pounds in 2005, had diabetes, high cholesterol and high blood pressure. Her cardiologist told her it all came back to ... (Source: USATODAY.com Health)
This column will change your life: Forgiveness
If hanging on to old resentments is bad for your health, what's the solution?Nothing in the lexicon of popular psychology triggers my inbuilt wince response quite so powerfully as the word "forgiveness". Apart from sheer cheesiness ? it's hardly unique in that respect, sadly ? there are several problems with the way self-help pontificators are always advising us to forgive. First, it seems like a concept best reserved for those who've undergone real trauma; I bridle, for example, at the "forgiveness guru" Colin Tipping's insistence that we all need to forgive our parents, apparently even if they were good parents ? as if not resenting them sufficiently were some kind of failing. Second, declaring yourself to have forgiven someone can sometimes be the height of pomposity, ev...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum
Ureaplasma species, the most commonly isolated microorganisms in women with chorioamnionitis, are associated with preterm delivery. Chorioamnionitis increases the risk and severity of bronchopulmonary dysplasia and persistent pulmonary hypertension in newborns. It is not known whether the timing of exposure to inflammation in utero is an important contributor to the pathogenesis of bronchopulmonary dysplasia. We hypothesized that chronic inflammation would alter the pulmonary air space and vascular development after 70 days of exposure to infection. Pregnant ewes were given intra-amniotic injection of Ureaplasma parvum serovars 3 or 6 at low (2 x 104 cfu) or high doses (2 x 107 cfu) or media (controls) at 55 days gestational age. Fetuses were delivered at 125 days (term = 150 days). U. par...
Effect of enalapril on plasma homocysteine levels in patients with essential hypertension.
Conclusions: Enalapril may cause an increase in plasma Hcy levels among the hypertensives with low baseline Hcy levels. There was no significant association between MTHFR C677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension. PMID: 20669348 [PubMed - as supplied by publisher] (Source: J Zhejiang Univ Sci ...)
Investigating mildly abnormal serum aminotransferase values
(Source: BMJ Online First)
First-line Latanoprost Therapy in Ocular Hypertension or Open-angle Glaucoma Patients: a 3-month Efficacy Analysis Stratified by Initial Intraocular Pressure
How effective is latanoprost in the treatment of both glaucoma and ocular hypertension? BMC Ophthalmology (Source: Medscape Today Headlines)
One third of young people suffer from high blood pressure
A worrying 35 per-cent of those aged 16-34 have hypertension, despite the widespread belief that it is an 'old age' problem. (Source: the Mail online | Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Pre-operative Gynecologic Evaluation of Bariatric Surgery Patients: Improving Cancer Detection in a High-Risk Population
Conclusions: Given the massive increases in morbid obesity and bariatric surgery in women, surgeons could serve a vital role in educating patients about both gynecologic and nongynecologic malignancy risks. With appropriate referral for cancer screening, patient outcomes could improve. (Source: Journal of the American College of Surgeons)
Med Sci Monit 2010; 16(8):PR9-14 "Efficacy and safety of intravenous stronger neo-minophagen C and S-adenosyl-L-methionine in treatment of pregnant woman with chronic hepatitis B: A pilot study"
Conclusions: Both SNMC and SAM improve liver function, with SNMC appearing more effective, in pregnant women with chronic hepatitis B without impact on fetal development. (Source: Medical Science Monitor)
Med Sci Monit 2010; 16(8):RA163-170 "Renal consequences of obesity"
The worldwide prevalence of obesity and its associated metabolic and cardiovascular disorders has risen dramatically within the past 2 decades. Our objective is to review the mechanisms that link obesity with altered kidney function. Current evidence suggests that excess weight gain may be responsible for 65?75% of the risk for arterial hypertension. Impaired renal pressure natriuresis, initially due to increased renal tubular sodium reabsorption, is a key factor linking obesity with hypertension. Obesity increases renal sodium reabsorption by activating the renin-angiotensin and sympathetic nervous systems, and by altering intrarenal physical forces. Adipose tissue functions as an endocrine organ, secreting hormones/cytokines (e.g., leptin) which may trigger sodium retention and hype...
Med Sci Monit 2010; 16(8):BR278-284 "Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle"
Conclusions: These results suggest that hypertrophied myocardial dysfunction may be attributed to changes in intracellular calcium cycling. (Source: Medical Science Monitor)
Music benefits the brain, research reveals
(NaturalNews) Northwestern University scientists have pulled together a review of research into what music -- specifically, learning to play music -- does to humans. The result shows music training does far more than allow us to entertain ourselves and others by playing an instrument or singing. Instead, it actually changes our brains.The paper, just published in Nature Reviews Neuroscience, is a compilation of research findings from scientists all over the world who used all kinds of research methods. The bottom line to all these studies: musical training has a profound impact on other skills including speech and language, memory and attention, and even the ability to convey emotions vocally. So what is it that musical training does? According to the Northwestern scientists, the findings ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Spontaneous hyphaema and acute ocular hypertension associated with severe lens-induced uveitis
Authors: S R Rathinam & E T Cunningham (Source: Eye)
Unichem Labs gets USFDA nod for hypertension tabs
Unichem Laboratories has received US FDA approval for bisoprolol fumarate and hydrochlorothiazide in tablet form, the drug regulator's website showed on Friday. Both drugs are used in the treatment of hypertension. (Source: The Economic Times Healthcare and Biotech News)
Calcium supplements in people with osteoporosis
(Source: BMJ Online First)
Myocardial Calcification and Hypertension following Chronic Renal Failure and Ameliorative Effects of Furosemide and Captopril
Cardiology 2010;116:194â€“205 (DOI:10.1159/000315146) (Source: Karger Publishers)
A prospective randomized study comparing cyclosporine versus tacrolimus combined with daclizumab, mycophenolate mofetil, and steroids in heart transplantation
Conclusions: Tac patients showed a tendency for longer time to first rejection, and there were more rejection-free patients with Tac and suffered fewer viral infections. Tac patients developed less hypertension and needed less drugs for its control. Renal function was similar in both groups. (Source: Clinical Transplantation)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
EDUCORE project: a clinical trial, randomised by clusters, to assess the effect of a visual learning method on blood pressure control in the primary healthcare setting
Discussion, The EDUCORE method could provide a simple, inexpensive means of improving blood pressure control, and perhaps other health problems, in the primary healthcare setting; Trial registration, The trial was registered with ClinicalTrials.gov, number NCT01155973 [http://ClinicalTrials.gov]. (Source: BMC Public Health - Latest articles)
Role of Endothelin and Inflammatory Cytokines in Pre-eclampsia – A Pilot North Indian Study
Conclusion We conclude that pre-eclampsia is associated with increased levels of both endothelin-1 and circulating inflammatory cytokines, which points toward the role of endothelial and inflammatory components. (Source: American Journal of Reproductive Immunology)
RCT: Nutritional intervention in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment - LOADD study
Source: BMJ Area: News This small randomised controlled trial (RCT) aimed to investigate how much intensive dietary intervention can influence glycaemic control and risk factors for cardiovascular disease in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment. The trial participants (n=93) were randomised to either intensive individualised dietary advice (n =45) according to the nutritional recommendations of the European Association for the Study of Diabetes) for six months or standard care (n=48, control). Both the intervention and control participants continued with their usual clinical care for diabetes (general practitioner or hospital diabetes clinic). Participants were aged <70 years with type 2 diabetes and a HbA1c of >7% despite optimised t...
[Comment] NO for preterm infants at risk of bronchopulmonary dysplasia
Although the initial clinical application of inhaled nitric oxide was for its vasodilatory role in pulmonary hypertension in term infants, nitric oxide showed positive effects in animal models of lung immaturity and lung injury: a reduction in lung inflammation, reduction in neutrophil infiltration into the lung, protection against oxidant lung injury, reversal of the effects of inhibition of vascular endothelial growth factor, and stimulation of angiogenesis and alveolarisation. On the basis of these findings, several studies were done to test the hypothesis that inhaled nitric oxide might preserve angiogenesis and alveolarisation, and therefore reduce lung injury and bronchopulmonary dysplasia. (Source: LANCET)
Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice.
Authors: Cuenca N, Pinilla I, FernÃ¡ndez-SÃ¡nchez L, Salinas-Navarro M, AlarcÃ³n-MartÃnez L, AvilÃ©s-Trigueros M, de la Villa P, Miralles de Imperial J, Villegas-PÃ©rez MP, Vidal-Sanz M In adult albino mice the effects of increased intraocular pressure on the outer retina and its circuitry was investigated at intervals ranging 3-14 weeks. Ocular hypertension (OHT) was induced by cauterizing the vessels draining the anterior part of the mice eye, as recently reported (Salinas-Navarro et al., 2009a). Electroretinographic (ERG) responses were recorded simultaneously from both eyes and compared each other prior to and at different survival intervals of 2, 8 or 12 weeks after lasering. Animals were processed at 3, 9 or 14 weeks after lasering, and radial sections were obtained ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303) [Gastrointestinal Cancer]
Conclusion The addition of bevacizumab to gemcitabine does not improve survival in advanced pancreatic cancer patients. (Source: Journal of Clinical Oncology)
Comparison of risk of neurovascular and cardiovascular side effects between tiotropium and other anticholinergic agents.
CONCLUSION: This observational study of recorded side effects showed that, except for stroke and hypertension, patients who were treated with an inhaled anticholinergic drug appeared to be at higher risk of developing neurovascular or cardiovascular side effects, than those treated with an oral drug. However, physicians should also be aware that oral anticholinergic drugs may have similar adverse impacts on health. Further studies on the association between anticholinergic drugs and cardiovascular and neurovascular side effects are recommended. PMID: 20659403 [PubMed - in process] (Source: Quality in Primary Care)
NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice
Sleep apnea (SA) is defined as intermittent respiratory arrest during sleep and affects up to 20% of the adult population. SA is also associated with an increased incidence of hypertension and peripheral vascular disease. Exposing rodents to intermittent hypoxia during sleep mimics the cyclical hypoxia/normoxia of SA. We have previously shown that in mice and rats intermittent hypoxia induces ET-1 upregulation and systemic hypertension. Furthermore, intermittent hypoxia (IH) in mice increases nuclear factor of activated T cells isoform 3 (NFATc3) transcriptional activity in aorta and mesenteric arteries, whereas the calcineurin/NFAT inhibitor cyclosporin A prevents IH-induced hypertension. More importantly, NFATc3 knockout (KO) mice do not develop IH-induced hypertension. The goals of this...
Elevated systemic TGF-{beta} impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE-/- mice
The role of circulating, systemic TGF-β levels in endothelial function is not clear. TGF-β1 may cause endothelial dysfunction in apolipoprotein E-deficient (apoE–/–) mice via stimulation of reactive oxygen species (ROS) production by the NADPH oxidase (NOX) system and aggravate aortic and heart remodeling and hypertension. Thoracic aorta (TA) were isolated from 4-mo-old control (C57Bl/6), apoE–/–, TGF-β1-overexpressing (TGFβ1), and crossbred apoE–/– x TGFβ1 mice. Endothelium-dependent relaxation was measured before and after incubation with apocynin (NOX inhibitor) or superoxide dismutase (SOD; ROS scavenger). Superoxide production within the vessel wall was determined by dihydroethidine staining under confocal microscope. In 8-m...
Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex
Following sinoaortic denervation, which eliminates arterial baroreceptor input into the brain, there are slowly developing adaptations that abolish initial sympathetic activation and hypertension. In comparison, electrical stimulation of the carotid sinus for 1 wk produces sustained reductions in sympathetic activity and arterial pressure. However, whether compensations occur subsequently to diminish these responses is unclear. Therefore, we determined whether there are important central and/or peripheral adaptations that diminish the sympathoinhibitory and blood pressure-lowering effects of more sustained carotid sinus stimulation. To this end, we measured whole body plasma norepinephrine spillover and 1-adrenergic vascular reactivity in six dogs over a 3-wk period of baroreflex activatio...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway
An increase in plasma ANG II causes neuronal activation in hypothalamic nuclei and a slow pressor response, presumably by increasing sympathetic drive. We evaluated whether the activation of a neuromodulatory pathway, involving aldosterone and "ouabain," is involved in these responses. In Wistar rats, the subcutaneous infusion of ANG II at 150 and 500 ng·kg–1·min–1 gradually increased blood pressure up to 60 mmHg at the highest dose. ANG II at 500 ng·kg–1·min–1 increased plasma ANG II by 4-fold, plasma aldosterone by 25-fold, and hypothalamic aldosterone by 3-fold. The intracerebroventricular infusion of an aldosterone synthase (AS) inhibitor prevented the ANG II-induced increase in hypothalamic aldosterone without affecting the increase ...
Ethnic differences in resistance artery contractility of normotensive pregnant women
Black women are at a greater risk to develop hypertension during pregnancy, with a 4.5 times higher rate of fatal preeclampsia than white women. Therefore, it is important to identify factors that may affect this risk. Our group previously proposed that high activity of the central regulatory enzyme of energy metabolism, creatine kinase (CK), may increase ATP-buffering capacity and lead to enhanced vascular contractility and reduced nitric oxide bioavailability. Therefore, we assessed microvascular contractility characteristics in isolated resistance arteries from self-defined black and white normotensive pregnant women using a Mulvany-Halpern myograph. Additionally, morphology was assessed with electron microscopy. Resistance-sized arteries obtained from omentum donated during cesarean se...
The importance of elastin to aortic development in mice
Elastin is an essential component of vertebrate arteries that provides elasticity and stores energy during the cardiac cycle. Elastin production in the arterial wall begins midgestation but increases rapidly during the last third of human and mouse development, just as blood pressure and cardiac output increase sharply. The aim of this study is to characterize the structure, hemodynamics, and mechanics of developing arteries with reduced elastin levels and determine the critical time period where elastin is required in the vertebrate cardiovascular system. Mice that lack elastin (Eln–/–) or have approximately one-half the normal level (Eln+/–) show relatively normal cardiovascular development up to embryonic day (E) 18 as assessed by arterial morphology, left ventricular ...
Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats
In conclusion, these results demonstrate that cardiac OTRs are involved in the regulation of cardiac function of OVX SHRs. The decreases of OTRs may contribute to cardiac pathology following menopause. (Source: AJP: Heart and Circulatory Physiology)
Ultrasound-detected subchorionic hemorrhage and the obstetric implications.
CONCLUSION:: Women with ultrasound-detected subchorionic hemorrhage before 22 weeks of gestation are at increased risk of placental abruption and preterm delivery but are not at increased risk of other adverse pregnancy outcomes. LEVEL OF EVIDENCE:: II. PMID: 20664390 [PubMed - in process] (Source: Obstetrics and Gynecology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Chorionic villus sampling at 11 to 13 weeks of gestation and hypertensive disorders in pregnancy.
CONCLUSION:: There is no association between performing a CVS in the first trimester and subsequent development of hypertensive disorders of pregnancy. LEVEL OF EVIDENCE:: II. PMID: 20664398 [PubMed - in process] (Source: Obstetrics and Gynecology)
Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy: A Meta-Analysis.
CONCLUSION:: Low-dose aspirin initiated in early pregnancy is an efficient method of reducing the incidence of preeclampsia and IUGR. PMID: 20664402 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
E-mail could be good for your patients? health
Source: Pamela Lewis Dolan, amednews Content: “There is a strong link between patients’ ability to e-mail physicians and improved patient outcomes, concludes a study conducted by Kaiser Permanente. Kaiser retrospectively observed 35,423 patients with diabetes, hypertension or both in its Southern California region from February 2005 to December 2008. It found that within any two-month period, [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
Dabigatran etexilate in people with atrial fibrillation
(Source: BMJ Online First)
Neighbourhood chronic stress and gender inequalities in hypertension among Canadian adults: a multilevel analysis
Conclusions Although future research is needed to determine whether interventions at the area-level are effective in reducing inequalities in health outcomes across neighbourhoods, policies aimed at reducing area-level deprivation may have a differential benefit on the cardiovascular health of men and women. (Source: Journal of Epidemiology and Community Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Antenatal screening and predicting hypertension in pregnancy for midwives
Conclusions: Further research should be focused on the factors observed by midwives during history taking and the antenatal course in the second and third trimesters and whether or not these can be synthesised in to a hypertension-specific diagnostic tool for use in midwifery practice. (Source: Women and Birth)
Role of GABA(B) Receptors in Autonomic Control of Systemic Blood Pressure.
Authors: Li DP, Pan HL GABA(B) receptors belong to family III G protein-coupled receptors (GPCRs) and are widely distributed in the peripheral and central nervous systems. The GABA(B) receptor is one of the most important therapeutic targets in the treatment for spasticity. GABA(B) agonists, such as baclofen, are used as muscle relaxants clinically and are effective for the treatment of anxiety, depression, epilepsy, and cognitive disorders (Caddick & Hosford, 1996; Dichter, 1997; Enna & Bowery, 1997). In addition, GABA(B) receptors regulate neurotransmitter release and neuronal excitability in the brain regions involved in the autonomic nervous system. Recent studies have led to a better understanding of the role of GABA(B) in the regulation of the autonomic nervous system, es...
Pharmaceutical drug contamination of waterways threatens life on our planet
This study was the first national-scale evaluation of pharmaceutical drug contamination in streams, and roughly 80 percent of the streams tested were found to be contaminated as well.In 2008, an AP investigation found that at least 46 million Americans are drinking water contaminated with trace amounts of pharmaceuticals. Even though every city tested has its water treated and "purified" prior to being delivered to the public, trace amounts of pharmaceutical drugs are making their way through to the tap. (Since not all major metropolitan areas were tested, the number of people affected is likely far higher than what was reported by AP.)In spite of all this, water quality reports don't disclose the levels of pharmaceuticals found in tap water. Since the EPA and FDA have failed to establish ...
Comparison of the efficacy and tolerability of telmisartan and enalapril in patients of mild to moderate essential hypertension
Conclusion : Telmisartan produces a greater reduction in diastolic BP than enalapril and is free from the adverse-effect of dry cough that is commonly encountered with enalapril. (Source: Indian Journal of Pharmacology)
Nocturnal Nondipping and Left Ventricular Hypertrophy in Hypertension: An Updated Review
The circadian rise and fall of blood pressure may have important links to cardiovascular diseases. Expert Review of Cardiovascular Therapy (Source: Medscape Cardiology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Middle Aortic Syndrome: Percutaneous Treatment With a Balloon-Expandable Covered Stent
A 46-year-old female patient was admitted with signs of lower limb ischemia. Her examination demonstrated a nonpalpable distal pulse. Computed tomography angiography revealed an anomalous origin of both renal arteries (A, B) and severe aortic narrowing between the renal arteries, confirmed by the angiogram (C). The diagnosis was middle aortic syndrome (). Endovascular treatment was decided on, and a balloon-expandable covered stent (Jomed, Abbott Laboratories, Abbott Park, Illinois) was placed, with good stent expansion (D). Physical examination revealed distal pulse recovery. At 5 months, the patient remains asymptomatic. Computed tomography angiography showed stent patency (E, F). Middle aortic syndrome refers to an isolated disease of the thoracoabdominal aorta causing segmental narrowi...
Oncology
(Source: BMJ Online First)
Risk factors associated with urinary albumin excretion in African Americans
Authors: K E Ussai, S W Keith, E Pequignot & B Falkner (Source: Journal of Human Hypertension)
Blood pressure elevation drives microalbuminuria
Authors: B J Materson & S Chandra (Source: Journal of Human Hypertension)
Review: Management of diabetes during Ramadan
This article in 'Diabetes Care' on the management of diabetes during Ramadan addresses the following topics:   . Pathophysiology of fasting   . Risks associated with fasting in patients with diabetes: hypoglycaemia, hyperglycaemia, diabetic ketoacidosis, dehydration and thrombosis   . Management: frequent monitoring of glycaemia, nutrition, exercise, breaking the fast, pre-Ramadan medical assessment, Ramadan-focused structured diabetes education   . Management of patients with type 1 and type 2 diabetes   . Management of diet-controlled patients   . Diabetic medication adjustment during Ramadan   . Pregnancy and fasting during Ramadan   . Management of hypertension and dyslipidae...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Thromboxane Synthase Inhibitors and Thromboxane A(2) Receptor Antagonists: A Quantitative Structure Activity Relationships (QSARs) Analysis.
Authors: Kontogiorgis C, Hadjipavlou-Litina D Thromboxane A(2) (TxA(2)), a bioactive metabolite of the Arachidonic acid (AA), is a potent mediator of platelet aggregation, vasoconstriction and bronchoconstriction. It plays an important role in major human diseases, such as myocardial infraction, unstable angina, pregnancy-induced hypertension and preeclampsia, thrombosis and thrombotic disorders, pulmonary hypertension, asthma, septic shock, atherosclerosis, lupus nephritis, and Raynaud's phenomenon. Thus, TxA(2) is a therapeutic target for many research groups. A number of TXA(2) receptor antagonists as well as thromboxane synthase inhibitors have been developed. In this research we review and evaluate new quantitative structure activity relationships of thromboxane synthase inhibitor...
Leptin Plasma Levels in the General Population: Influence of Age, Gender, Body Weight and Medical History.
Authors: Fulda S, Linseisen J, Wolfram G, Himmerich S, Gedrich K, PollmÃ¤cher T, Himmerich H The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in men, the association of leptin levels and age in women is an issue of scientific discussion. To investigate the association of age, gender, body mass index (BMI) and selected diseases with plasma levels of leptin in 551 adults randomly chosen from the Bavarian population, we assessed subjects' characteristics, lifestyle, and medical history including life time history of frequent ...
Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones?Role of Age and Comorbid Diseases
Author Summary Chronic kidney disease (CKD) is a common condition that is associated with substantial morbidity and mortality and has been recognized as a major public health problem worldwide. Common causes of CKD include hypertension, diabetes, and inflammatory disorders. Previous studies have shown a significant genetic contribution to kidney disease and a recent genome-wide association study yielded a variant in the UMOD gene that affects the risk of CKD. Here, we replicate the association between UMOD and CKD in an independent analysis. We also demonstrate for the first time an interaction between the UMOD variant and age that suggests that this variant may adversely affect the aging kidney and its adaptation to age-related risk factors of kidney disease, such as hypertension and dia...
Salty Foods May Be Worse for You Than You Realize
There are few out there who can resist indulging in salty foods now and again, whether their weakness is french fries, potato chips, movie popcorn or a bloody Mary. While having these foods every once in awhile isn’t a big deal health wise, it’s the salt that lurks in expected places that might be hurting you most. Many people don’t realize just how much sodium is in many of the foods they eat, and just what kind of negative effects it may be having on their bodies. The average adult shouldn’t consume more than 2400 mg of sodium a day, but many may be doing so quite unaware of how much salt is really in their food. Take canned soups for instance. Many are seemingly healthy, touting low calories and fat but masking an incredibly high amount of sodium (after all, they...
Electronic Records May Help Improve BP Control
Source: John Schieszer, Renal And Urology News Content: “New findings suggest that electronic health records (EHR) with special features for managing hypertension may be highly beneficial in improving BP control. Numerous approaches have been employed to improve BP control, including increasing patient involvement, improving patient compliance, reversing physician inertia, improving lifestyle modifications, and optimizing pharmacologic therapy. [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Are Primary Care Providers Uncomfortable Providing Routine Preventive Care for Inflammatory Bowel Disease Patients?
Conclusions  Our study suggests that family medicine practitioners often do not feel comfortable providing care to IBD patients. Lack of familiarity with IBD medications may be a key factor. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1329-8Authors Lisbeth Selby, University of Kentucky Medical Center Department of Internal Medicine, Division of Digestive Diseases and Nutrition MN 649 Lexington KY 40536 USAAndrew Hoellein, University of Kentucky Medical Center Department of Internal Medicine, Division of General Internal Medicine K509 Kentucky Clinic Lexington KY 40536-0284 USAJohn F. Wilson, University of Kentucky Department of Behavioral Science 123 College of Medicine Office Building Lexington KY 40536-0086 USA Journal Digestiv...
Soft Endpoint Sought for Pediatric PAH Trial
(MedPage Today) -- An FDA advisory panel will revisit an increasingly familiar battleground this week, as it considers whether a drug sponsor can substitute a surrogate endpoint for a clinical outcome in a pediatric pulmonary arterial hypertension (PAH) trial. (Source: MedPage Today Public Health)
The Role of Cellular Micronutrient Analysis, Nutraceuticals, Vitamins, Antioxidants and Minerals in the Prevention and Treatment of Hypertension and Cardiovascular Disease
Diagnosis and treatment of nutrient deficiencies may reduce blood pressure and reduce cardiovascular events. Therapeutic Advances in Cardiovascular Disease (Source: Medscape Nephrology Headlines)
New weight advice for pregnancy
Many newspapers have reported on new official guidelines for how women can manage their weight before, during and after pregnancy. The advice comes from the National Institute for Health and Clinical Excellence (NICE). The importance of the guidelines are borne out by figures suggesting that more mothers than ever are overweight. The Guardian suggests that, ?15-20% of women getting pregnant are overweight or obese?. The Daily Mail puts the number higher, saying that ?almost half of expectant mothers are overweight or obese?. It goes on to spell out the dangers of being obese or overweight during pregnancy, which include ?fatal health conditions such as blood clots, pre-eclampsia, miscarriages and stillbirths?. The newspapers also dispel the myth that women should eat for two du...
Researchers Identify Risks Of Hypertension In Young Adults
Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls. According to the study published in Hypertension: Journal of the American Heart Association, the research team assessed how teenage boys and girls with normal blood pressure might progress into becoming young adults with hypertension... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
FDA Approves Tribenzor?, A New Three-In-One Combination Product For The Treatment Of High Blood Pressure
Daiichi Sankyo, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved TRIBENZOR? (olmesartan medoxomil, amlodipine, hydrochlorothiazide), a new three-in-one combination product taken once-daily for the treatment of hypertension in patients who are not adequately controlled on any two of the following antihypertensive[1] drug classes: angiotensin receptor blockers, calcium channel blockers and diuretics. TRIBENZOR is not indicated for initial therapy... (Source: Health News from Medical News Today)
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways
Peroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress. In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium. New functions of PPARs are reported in the arrhythmogenic right ventricular cardiomyopathy, a human genetic heart disease. It is now possible to link the genetic desmosomal abnormalitiy to the presence of fat in the right ventricle, partly due to an overexpression of PPARγ. Moreover, PPARs are...
Increased Pulmonary Pressures and Myocardial Wall Stress in Children with Severe Malaria
Conclusion.?Children with severe malaria have increased pulmonary pressures and myocardial wall stress. These complications are consistent with NO depletion from intravascular hemolysis, and they indicate that the pathophysiologic cascade from intravascular hemolysis to NO depletion and its cardiopulmonary effects is activated in children with severe malaria. (Source: The Journal of Infectious Diseases Latest Issue)
Botulinum toxin-induced relaxation of the sphincter of Oddi may select patients with acalculous biliary pain who will benefit from cholecystectomy
Conclusion  Botulinum toxin-induced relaxation of the SO may help to direct appropriate therapy for patients with acalculous biliary pain. The data from this study supports the establishment of a randomized clinical trial. Content Type Journal ArticleDOI 10.1007/s00464-010-1260-2Authors William R. Murray, Glasgow Royal Infirmary Lister Department of Surgery Glasgow G31 2ER Scotland UK Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)
Sarcoidosis-Associated Pulmonary Hypertension: Assessment and Management
This article reviews the most recent data available in the epidemiology, pathophysiology, diagnosis, and treatment of SAPH.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text (Source: Seminars in Respiratory and Critical Care Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Health Insurance and Cardiovascular Disease Risk Factors
Conclusion: The treatment and control of hypertension and hypercholesterolemia are lower among uninsured adults. Increasing the proportion of insured individuals may be a means to improve the treatment and control of cardiovascular disease risk factors and to reduce health disparities. (Source: The American Journal of Medicine)
Prevalence and Characteristics of Tinnitus among US Adults
Conclusions: The prevalence of frequent tinnitus is highest among older adults, non-Hispanic whites, former smokers, and adults with hypertension, hearing impairment, loud noise exposure, or generalized anxiety disorder. Prospective studies of risk factors for tinnitus are needed. (Source: The American Journal of Medicine)
Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy
Abstract: Background: Our understanding of the growing population of very old patients (aged ?80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes.Methods: This was a secondary analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable hypertensive coronary artery disease patients aged ?50 years. The patients were grouped by age in 10-year increments (aged ?80, n=2180; 70? (Source: The American Journal of Medicine)
Impact Of Childhood Obesity Goes Beyond Health
Adults who have been overweight since high school risk a lifetime of disease, discrimination and poverty. A new study of obese 40-year-olds found those who were overweight teens were three times more likely to suffer chronic health problems such as heart disease, diabetes and hypertension. They were also much more likely to be unemployed or receiving welfare.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)
Body mass index at age 17 within the normal range can predict future risk for hypertension in later life
How might teenage boys and girls with normal blood pressure might progress into becoming young adults with hypertension? Boys are three to four times more likely to develop hypertension as young adults and the higher the blood pressure value, even within the normal range, the higher is the risk for becoming hypertensive adults, according to new research. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Adrenergic Signaling Polymorphisms and Their Impact on Cardiovascular Disease
This review examines the impact of recent discoveries defining personal genetics of adrenergic signaling polymorphisms on scientific discovery and medical practice related to cardiovascular diseases. The adrenergic system is the major regulator of minute-by-minute cardiovascular function. Inhibition of adrenergic signaling with pharmacological β-adrenergic receptor antagonists (β-blockers) is first-line therapy for heart failure and hypertension. Advances in pharmacology, molecular biology, and genetics of adrenergic signaling pathways have brought us to the point where personal genetic differences in adrenergic signaling factors are being assessed as determinants of risk or progression of cardiovascular disease. For a few polymorphisms, functional data generated in cell-based sy...
In vivo assessment of the hepatic microcirculation after mesenterico-portal bypass (REX-shunt) using orthogonal polarization spectral imaging
This study investigates the hepatic microcirculation before and after REX-shunt interposition using orthogonal polarization spectral imaging (OPS). Since 2004, three consecutive patients with extrahepatic portal vein thrombosis underwent REX-shunt interposition. We measured the hepatic microcirculation by OPS before and directly after REX-shunt reperfusion and analysed the capillary vessel diameter, red blood cell velocity, functional capillary density and volumetric blood flow. Furthermore, we compared our values with the physiological values of the hepatic microcirculation defined previously by other investigators. All shunts showed an excellent function in the follow-up investigations. The intra-individual microcirculatory analysis revealed a reduction in the red blood cell velocity aft...
CCGMP Pulmonary Disease Chapter 11 - Pulmonary Hypertension
(Source: Modern Medicine)
CCGMP Pulmonary Disease Chapter 11 - Pulmonary Hypertension
(Source: Modern Medicine)
Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats.
Authors: Sabuhi R, Asghar M, Hussain T A positive association between renin angiotensin system, especially AT1 receptor and oxidative stress in the pathogenesis of hypertension and cardiovascular/renal diseases has been suggested. However, the role of oxidative stress, especially superoxide radicals in renal sodium handling in response to AT1 and AT2 receptors is not known. Therefore, the present study was designed to investigate the role of NAD(P)H oxidase (NOX), a major superoxide radical producing enzyme, in AT1 and AT2 receptor function on natriuresis/diuresis in SD rats. The rats under anesthesia were intravenously infused with NOX inhibitor apocynin (3.5 mug/kg/min), the AT1 receptor antagonist candesartan (100 mug/kg; bolus) and the AT2 receptor agonist CGP- 42112A (1 mug/kg/min...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in ren-2 transgenic rats.
In conclusion, aliskiren and losartan had similar antihypertensive effects during chronic treatment, but the antihypertensive and organoprotective effects of aliskiren were persistent even after the 12-day washout period. The durable effect on proteinuria can possibly be attributed to the normalization of glomerular morphology. PMID: 20668096 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Moderate hyperbilirubinemia improves renal hemodynamics in angiotensin ii dependent hypertension.
MODERATE HYPERBILIRUBINEMIA IMPROVES RENAL HEMODYNAMICS IN ANGIOTENSIN II DEPENDENT HYPERTENSION. Am J Physiol Regul Integr Comp Physiol. 2010 Jul 28; Authors: Vera T, Stec DE We have previously demonstrated that moderate hyperbilirubinemia decreases blood pressure in Angiotensin (Ang) II-dependent hypertension through mechanisms that decrease oxidative stress and increase nitric oxide levels. Since decreases in renal hemodynamics play an important role in mediating the hypertensive actions of Ang II, the goal of the present study was to examine the effect of moderate hyperbilirubinemia on glomerular filtration rate (GFR) and renal blood flow (RBF) in a mouse model of Ang II hypertension. Mice were made moderately hyperbilirubinemic by two methods: Indinavir or specific morphol...
Efficacy of amiodarone on refractory ventricular fibrillation resistant to lidocaine and cardioversion during weaning from cardiopulmonary bypass in aortic valve replacement for severe aortic stenosis with left ventricular hypertrophy
Abstract  Intravenous injection of amiodarone, a class III anti-arrhythmic is widely used for persistent refractory arrhythmias. We present a case report suggesting the efficacy of amiodarone in refractory ventricular fibrillation (Vf) during weaning from cardiopulmonary bypass (CPB). A 66-year-old woman with hypertension had a medical examination as a result of an episode of palpitations and syncope. Echocardiography and an invasive hemodynamic study revealed severe aortic stenosis (AS) with left ventricular (LV) hypertrophy because of calcified degeneration in a congenital bicuspid aortic valve (AV). Aortic valve replacement (AVR) was scheduled under general anesthesia and CPB. Intraoperative diagnosis was AS with calcified AV, LV hypertrophy, and aneurysm of ascending ao...
Renal artery stenosis with significant proteinuria may be reversed after nephrectomy or revascularization in patients with the antiphospholipid antibody syndrome: a case series and review of the literature
Abstract  Renal artery stenosis (RAS) is a disease which might present as hypertension, renal insufficiency or proteinuria and even as nephrotic syndrome. While 90% of cases are secondary to atherosclerosis, the rest of the cases are usually related to fibromuscular dysplasia. Recently, RAS has also been documented in patients with the antiphospholipid syndrome (APS). Although cases of nephrotic syndrome induced by RAS have been published, cases of patients with APS and nephrotic syndrome attributed to RAS were not reported in the literature. In this paper, three young male patients with APS, hypertension and significant proteinuria secondary to RAS are presented. The patients were treated with nephrectomy or revascularization in addition to prior treatment with warfarin, w...
Smoking May Worsen Outcome of Pregnancy Complication
A new study suggests that smokers who develop preeclampsia during pregnancy are at particular risk of suffering the complications associated with the disorder -- including preterm delivery, low birth weight and stillbirth.Source: Reuters Health Related MedlinePlus Pages: High Blood Pressure in Pregnancy, Pregnancy and Substance Abuse (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Prevalence and Diagnosis of Primary Aldosteronism
Abstract  Primary aldosteronism (PA) is a common cause of arterial hypertension: in the PA Prevalence in Hypertensives (PAPY) Study, the prevalence of PA was 11.2% in consecutive referred hypertensive patients. When adrenal vein sampling (AVS) is available, two thirds of the cases can be attributed to a tumor and one third of cases are idiopathic; the opposite is seen when AVS is unavailable. Thus, AVS influences the relative prevalence rate of the main subtypes of PA. When adrenalectomy is undertaken based on AVS, almost 100% of patients are cured of hyperaldosteronism, one third are cured of hypertension, and 52% are markedly improved in terms of blood pressure control. Persistent hypertension can be predicted by a long history of hypertension and by the presence of exces...
Surgical Approach for Aortic Coarctation Influences Arterial Compliance and Blood Pressure Control [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]
Conclusions Young children undergoing SFR have higher blood pressure and stiffer upper limb arteries compared with matched children undergoing EEA. Our data suggest that better longer-term cardiovascular outcome is to be expected with the EEA surgical approach. (Source: The Annals of Thoracic Surgery)
Ben-Gurion University of the Negev Researchers Identify Risks of Hypertension in Young Adults
July 27, 2010 (EurekAlert) - Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls. read more (Source: Diabetes News from dLife.com)
Ben-Gurion University of the Negev Researchers Identify Risks of Hypertension in Young Adults
July 27, 2010 (EurekAlert) - Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls. read more (Source: Diabetes News from dLife.com)
Aliskiren Versus Ramipril in Hypertension
Three studies are compared to evaluate the antihypertensive effects of these two monotherapies. Therapeutic Advances in Cardiovascular Disease (Source: Medscape Nephrology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
New proteins that regulate blood pressure, flow discovered
Researchers have identified key players in a little-known biochemical pathway that appears to regulate blood pressure. The findings could lead to a better understanding of who will get high blood pressure and why, as well as allow us to develop better drugs to treat these patients. (Source: ScienceDaily Headlines)
Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation
Conclusion Common non-synonymous genetic variants within NPPA in these two large North American cohorts of European ancestry are not associated with the development of AF. (Source: Europace)
FDA Alert - Vialipro Dietary Supplement Recalled: Undeclared Drug Ingredient
The undeclared ingredient may pose a threat to the consumer because the interaction of the analogue with some prescription drugs (such as nitroglycerin) may lower blood pressure to dangerous levels. Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take other prescription drugs. (Source: NCCAM Featured Content)
Mycophenolic acid in Rheumatology: mechanisms of action and severe adverse events.
Authors: Zizzo G, De Santis M, Ferraccioli GF Mycophenolic acid (MPA) is an immunosuppressive agent, more and more extensively used in transplantation, rheumatology and nephrology. In this review, we will analyze the molecular mechanisms of its action, including the newest insights, in particular the inhibition of lymphocytes and the induction of tolerogenic dendritic cells (DCs) and its direct effects on non-immune cells (fibroblasts and myofibroblasts, mesangial cells, vascular smooth muscle cells [VSMC], endothelial cells). The latters suggest new therapeutic indications, specifically fibrosis (i.e. glomerulosclerosis and interstitial lung diseases), vascular damage and pulmonary hypertension, which represent key pathogenic features in connective tissue diseases. Given the differenc...
First Nations People On Peritoneal Dialysis At Greater Risk Of Infection And Death
First Nations people in Canada on peritoneal dialysis are at increased risk of peritonitis and death, irrespective of whether they live in a rural or urban location, found a study published in CMAJ (Canadian Medical Association Journal). The high prevalence of diabetes, obesity and hypertension in Canada's First Nations, or aboriginal, population is fuelling the rapid growth of kidney disease and renal failure and consequent need for care and dialysis. Peritonitis is inflammation of the peritoneum (the inner lining of the abdominal and pelvic walls), often caused by infection... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Scientists discover olive oil directly impacts genes to halt inflammation
(NaturalNews) Research has been steadily accumulating that olive oil, a main component of the Mediterranean diet, has extensive health-protective properties. For example, phytonutrient components of olive oil have been found to be effective against breast cancer cells (http://www.naturalnews.com/025633_cancer_olive_oil_brst.html) and studies suggest the abundance of olive oil in the Mediterranean style of eating may be the reason that diet helps prevent depression (http://www.naturalnews.com/027265_depression_mediterranean_diet_health.html). Now scientists have discovered that phenolic compounds in olive oil directly repress genes linked to inflammation. This could be especially important in halting the dangerous effects of metabolic syndrome. Characterized by excess abdominal fat, high ch...
CHMP Adopts Positive Opinion For TWYNSTA(R), Boehringer Ingelheim's New Single Pill Combination Hypertension Treatment
Boehringer Ingelheim announced that the European Committee for Medicinal Products for Human Use (CHMP) adopted a Positive Opinion for the approval of TWYNSTA®. It will be indicated in adults whose blood pressure is not adequately controlled on amlodipine and is also indicated as replacement therapy in adult patients receiving telmisartan and amlodipine from separate tablets can instead receive tablets of TWYNSTA containing the same component doses... (Source: Health News from Medical News Today)
amlodipine and valsartan (Exforge)
Title: amlodipine and valsartan (Exforge)Category: MedicationsCreated: 7/27/2010 3:42:00 PMLast Editorial Review: 7/27/2010 3:42:20 PM (Source: MedicineNet High Blood Pressure General)
Combination Drug Approved for High Blood Pressure
Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet High Blood Pressure General)
To Help Keep Weight Off, Turn to the Web
Title: To Help Keep Weight Off, Turn to the WebCategory: Health NewsCreated: 7/27/2010 8:10:00 AMLast Editorial Review: 7/27/2010 (Source: MedicineNet High Blood Pressure General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Combination Drug Approved for High Blood Pressure
Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Senior Health General)
Combination Drug Approved for High Blood Pressure
Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Migraine General)
Combination Drug Approved for High Blood Pressure
Title: Combination Drug Approved for High Blood PressureCategory: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Digestion General)
Ben-Gurion University of the Negev researchers identify risks of hypertension in young adults
(American Associates, Ben-Gurion University of the Negev) According to the study published in Hypertension, the American Heart Association journal, the research team assessed how teenage boys and girls with normal blood pressure might progress into becoming young adults with hypertension. Currently, systolic blood pressures of 100 to 110 and even up to 120 are considered within the normal range for adolescents. Other traits like weight, height and body mass index have a range of distribution that is considered "normal." (Source: EurekAlert! - Social and Behavioral Science)
A phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas
The authors evaluated a 3-week schedule of bevacizumab in patients with recurrent high-grade glioma (HGG).Patients received bevacizumab 15 mg/kg every 3 weeks and were evaluated every 6 weeks until tumor progression. Tissue correlates were used to quantify tumor content of vascular endothelial growth factor A (VEGFA) and vascular endothelial growth factor receptor-2 (VEGFR2).Of 61 patients who were treated (35 men and 26 women; median age, 52 years; age range, 21-78 years), 50 patients had glioblastoma multiforme (GBM), and 11 patients had anaplastic glioma (AG). The median number of previous chemotherapies was 2 (range, 1-5 previous chemotherapies), and 16 patients had received [ge]3 previous chemotherapies. The median number of bevacizumab doses was 4 (range, 1-20 doses), and 45% of pati...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension
Authors: S Francque, A Verrijken, I Mertens, G Hubens, E Van Marck, P Pelckmans, P Michielsen & L Van Gaal (Source: International Journal of Obesity)
eNOS haplotype associated with hypertension in obese children and adolescents
Authors: D C Souza-Costa, V A Belo, P S Silva, I F Metzger, C M Lanna, M A Machado & J E Tanus-Santos (Source: International Journal of Obesity)
The possibility of microarray-based analysis using cell-free placental mRNA in maternal plasma
The purpose of this study is to investigate a possibility of overall assessment of cell-free (CF) placental mRNAs in maternal plasma.First, placenta-predominantly expressed transcripts were selected by the analysis of GeneChip using three sets of placental tissues and corresponding maternal blood cells. Subsequently, a custom cDNA array panel of placenta-predominantly expressed transcripts was designed and used to compare the RNA profiles of maternal plasma collected from 12 preeclamptic and 12 uncomplicated pregnancies. Scatter plots for the signal intensities of the comparative cDNA hybridization revealed either unchanged or aberrant patterns.We selected top 50 placenta-predominantly expressed transcripts that were > 2500 times higher in placental tissues than in corresponding whole bloo...
Detection and Treatment of Resistant Hypertension
Abstract  The evaluation of patients with resistant hypertension should be directed toward confirming true treatment resistance, identifying the causes contributing to treatment resistance (including secondary causes of hypertension), and documenting target-organ damage. Treatment of resistant hypertension is aimed at reversing lifestyle factors contributing to treatment resistance, accurately diagnosing and appropriately treating secondary causes of hypertension, and effectively using multidrug regimens. Lifestyle changes, pharmacologic therapies, and nonpharmacologic therapies have all shown benefits in patients with resistant hypertension, but much additional knowledge is needed to better identify and treat these patients. Content Type Journal ArticleDOI 10.1007/s119...
FDA Approves Another Triple-Drug Combination for Resistant Hypertension: Tribenzor
The new product combines the angiotensin-receptor blocker olmesartan, the calcium-channel blocker amlodipine, and the diuretic hydrochlorothiazide. Heartwire (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
FDA Okays New Hypertension Polypill
WASHINGTON (MedPage Today) -- The FDA has approved a combination of three hypertension drugs -- olmesartan medoxomil, amlodipine, and hydrochlorothiazide (Tribenzor) -- to treat patients whose blood pressure is not controlled on angiotensin receptor blockers, calcium channel blockers, or diuretics. (Source: MedPage Today Public Health)
Combination Drug Approved for High Blood Pressure
Tribenzor sanctioned for those who don't respond to other drugs (Source: The Doctors Lounge - Cardiology)
FDA approves another triple-drug combination for resistant hypertension: Tribenzor
The new product combines the angiotensin-receptor blocker olmesartan, the calcium-channel blocker amlodipine, and the diuretic hydrochlorothiazide. For complete story visit theheart.org. (Source: theHeart.org)
Combination Drug Approved for High Blood Pressure
Tribenzor sanctioned for those who don't respond to other drugsSource: HealthDay Related MedlinePlus Pages: Blood Pressure Medicines, High Blood Pressure (Source: MedlinePlus Health News)
Imatinib Promising for Refractory Pulmonary Artery Hypertension
The tyrosine kinase inhibitor (TKI) imatinib is a useful add-on treatment when pulmonary artery hypertension (PAH) hasn't responded to standard therapy, according to a European study. Reuters Health Information (Source: Medscape Medical News Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Daiichi nets FDA nod for 3-in-1 hypertension med
The FDA has approved Daiichi Sankyo's olmesartan medoxomil/amlodipine/hydrochlorothiazide (Tribenzor), a three-in-one combination product taken once-daily for the treatment of hypertension in patients who are not adequately controlled on the following antihypertensive drug classes: angiotensin receptor blockers, calcium channel blockers and diuretics. (Source: Cardiovascular Business News)
FDA Approves Tribenzor, A New Three-In-One Combination Product for the Treatment of High Blood Pressure
One in Three US Adults Have Hypertension and Many Are Uncontrolled on Two or More Antihypertensive Medications(1) PARSIPPANY, N.J., July 26 (HSMN NewsFeed) -- Daiichi Sankyo, Inc. announced today that the U.S. Food and Drug Administration (FDA) approv... Biopharmaceuticals, FDADaiichi Sankyo, TRIBENZOR, hypertension (Source: HSMN NewsFeed)
FDA Approves Tribenzor, A New Three-In-One Combination Product for the Treatment of High Blood Pressure
PARSIPPANY, N.J., July 26 /PRNewswire/ -- Daiichi Sankyo, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide), a new three-in-one combination product... (Source: Drugs.com - New Drug Approvals)
IVF death risk 'overstated'
Conclusion This cross-sectional study determined the rate of deaths due to IVF treatment or pregnancies in the Netherlands between 1984 and 2008. The Daily Telegraph?s headline and report are potentially misleading. The news article focuses primarily on the increased risk of women?s bodies rejecting donated eggs or underlying health problems coming to the fore. However, it is a fact that women who have IVF tend to be older, and are therefore at greater risk of having adverse outcomes. Also, the report that risk of death is three times higher than natural conceptions fails to mention that the actual number of women who died of potential IVF related problems in this study remained relatively low, at only 43 for every 100,000 women who had IVF. There are a number of important points to co...
Prolonged infusions of dexmedetomidine in critically ill patients.
Conclusion Dexmedetomidine is an alternative to traditional sedatives and analgesics in critically ill patients. The safety and efficacy of dexmedetomidine in adults likely persist beyond 24 hours, without the emergence of rebound effects after discontinuation. PMID: 20651314 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Great Tastes And International Recipes That Reduce The Risk Of Heart Disease
The European Society of Cardiology (ESC) has announced the upcoming launch of its all-new European Cook Book. Bringing together recipes created by leading cardiologists from across its membership, the aim of this high quality book is to demonstrate that a diverse, heart-friendly diet can be achieved without compromising on taste. The ESC strongly endorses a healthy and balanced diet as an effective means of lowering the risks from conditions such as hypertension, diabetes and coronary artery disease... (Source: Health News from Medical News Today)
As Weight Goes Up, So Do Heart Risks
Title: As Weight Goes Up, So Do Heart RisksCategory: Health NewsCreated: 7/23/2010 12:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet High Blood Pressure General)
Shedding Pounds Saved One Woman's Life
Title: Shedding Pounds Saved One Woman's LifeCategory: Health NewsCreated: 7/23/2010 12:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet High Blood Pressure General)
Relationship Insecurity May Undermine Your Health
Title: Relationship Insecurity May Undermine Your HealthCategory: Health NewsCreated: 7/24/2010 8:10:00 AMLast Editorial Review: 7/26/2010 (Source: MedicineNet High Blood Pressure General)
EU committee recommends Boehringer's hypertension drug for approval
The European Committee for Medicinal Products for Human Use has adopted a Positive Opinion for the approval of Boehringer Ingelheim?s single pill combination hypertension drug telmisartan/amlodipine (Twynsta). (Source: Cardiovascular Business News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
No harm from relaxed antihypertensive strategy in acute stroke
Stopping pre-existing antihypertensive treatment for 2 weeks after an acute stroke does not appear to harm patients, show the results of the COSSACS trial. (Source: MedWire News - Hypertension)
Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu
Background: Obesity is a pro-inflammatory state frequently associated with widespread metabolic alterations that include insulin resistance and deregulation of blood pressure (BP). This cascade of events in some measure explains the susceptibility of obese adults for co-morbid conditions like diabetes mellitus and hypertension.Hypothesis: We hypothesized that an elevated systemic proinflammatory burden correlates with dysglycemia and deregulated blood pressure. Methods: We analyzed the screening anthropometric and laboratory measures from healthy disease free obese adults (n=35; women (W) 27, men (M) 8) in a weight loss study. Results: Healthy obese normoglycemic (fasting serum glucose: FSG (Source: Journal of Inflammation)
CHMP recommends EU approval of combination telmisartan/amlodipine product (Twynsta®)
Source: European Medicines Agency (EMA) Area: News The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended that the combination product Twynsta® (telmisartan/amlodipine) be given a marketing authorisation for the treatment of essential hypertension. (Source: NeLM - News)
Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course. Longitudinal Observations From the Framingham Heart Study.
Conclusions-Cardiac remodeling over the adult life course is characterized by a distinct pattern of increasing LV wall thickness, decreasing LV dimensions, and increasing fractional shortening with advancing age. Overall, female sex, greater blood pressure load, and presence of diabetes mellitus serve to attenuate this remodeling pattern. These observations suggest a mechanism for the preponderance of women with hypertension and individuals with diabetes among patients with diastolic heart failure. PMID: 20660804 [PubMed - as supplied by publisher] (Source: Circulation)
Hypertension in Pregnancy and Later Cardiovascular Risk. Common Antecedents?
Conclusions-These results suggest that the positive association of preeclampsia and gestational hypertension with postpregnancy cardiovascular risk factors may be due largely to shared prepregnancy risk factors rather than reflecting a direct influence of the hypertensive disorder in pregnancy. PMID: 20660802 [PubMed - as supplied by publisher] (Source: Circulation)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Time to abandon small-sample cohort research in health psychology?
Comments on the original article, "Avoidant coping as a predictor of mortality in veterans with end-stage renal disease" by E. J. Wolf and D. L. Mori (see record 2009-06704-009), in which the authors report that among 61 patients with endstage renal disease (ESRD), avoidant coping more than doubled the odds of mortality in multivariable analysis. The authors concluded that evaluating coping style in patients with ESRD would be clinically useful and that interventions targeting avoidant coping should be investigated. In this commentary, the current authors note that Wolf and Mori?s (2009) finding was based on a sample where only 23 patients died over 9 years, and results were evaluated using a Cox regression model with six covariates, a ratio of only 3.8 outcome events per variable?well...
Associations between adult attachment ratings and health conditions: Evidence from the National Comorbidity Survey Replication.
Conclusion: The findings were generally supportive of the theory that insecure attachment is a risk factor for the development of disease and chronic illness, particularly conditions involving the cardiovascular system. Further research regarding the role of attachment in the development of specific health conditions is warranted. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (Source: Health Psychology)
Relationship Insecurity May Undermine Your Health
People who feel anxious and needy at higher risk of heart disease, high blood pressure, chronic pain and stroke, researchers findSource: HealthDay Related MedlinePlus Pages: Heart Diseases, Mental Health (Source: MedlinePlus Health News)
Applying Ontology Techniques to Develop a Medication History Search and Alert System in Department of Nuclear Medicine
Source: Chen J et al, Journal of Medical Systems, 2010 Content: Nowadays, patients usually take more than three drugs for diseases such as hypertension, diabetes, and dyslipidemia. Hence, nuclear medicine physicians should be very careful about the medication history of each patient and ensure that their medication will not cause false positive or false negative [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
Effect of an Olmesartan Medoxomil-Based Treatment Algorithm on Systolic Blood Pressure in Patients with Stage 1 or 2 Hypertension: A Randomized, Double-Blind, Placebo-Controlled Study
(Source: American Journal of Cardiovascular Drugs)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Trends for type 2 diabetes and other cardiovascular risk factors in Mexico from 1993-2006.
CONCLUSIONS: This increasing trends for the prevalence of T2D and cardiovascular risk factors predicts larger increments in the near future for T2D and cardiovascular morbidity and mortality. Intensification of the preventive and remedy strategies is mandatory in order curve the foreseen dramatic increment in the disease burden. PMID: 20585732 [PubMed - in process] (Source: Salud Publica de Mexico)
Hypertension in Mexican adults: results from the National Health and Nutrition Survey 2006.
CONCLUSIONS: Hypertension is one of the most prevalent chronic diseases in Mexico. In the last six years in Mexico, a substantial increase (25%) has been observed in contrast to the reduction seen among Mexican-Americans (-15%). PMID: 20585731 [PubMed - in process] (Source: Salud Publica de Mexico)
Methodology for the analysis of type 2 diabetes, metabolic syndrome and cardiovascular disease risk indicators in the ENSANUT 2006.
CONCLUSIONS: The randomly selected sub-sample was not essentially different from the rest of the fasting subjects. Thus, no bias is expected in the interpretation of cardiovascular risk indicators derived from these data. PMID: 20585728 [PubMed - in process] (Source: Salud Publica de Mexico)
Significance of serum uric acid in pulmonary hypertension due to systemic sclerosis: a pilot study
Abstract  Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to investigate the potent relationship between serum UA and pulmonary pressure as well as functional capacity in patients with SSc. We studied 66 patients (mean age 57.7 ± 12.1 years, 63 women), presenting with SSc. Systolic pulmonary artery pressure assessed by echocardiography, lung function tests, six-minute walk test (6MWT) and serum UA levels were recorded in all patients. In 24 (36%) patients, the diagnosis of PH was established by echoca...
Comparing self-reported and measured high blood pressure and high cholesterol status using data from a large representative cohort study.
Conclusion: Although self-reported measures are consistent over time there are major differences between the self-reported measures and the actual clinical measurements. Technical aspects associated with clinic measurements could explain some of the difference. Implications: Monitoring of these broad population measures requires knowledge of the differences and limitations in population settings. PMID: 20649780 [PubMed - in process] (Source: Australian and New Zealand Journal of Public Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Usefulness of multi-detector helical CT with multiplanar reconstruction for depicting the duodenal varices with multiple collateral shunt vessels
We report the case of a 58-year-old man with liver cirrhosis with repeated bleeding from duodenal varices. Esophagogastroduodenoscopy (EGD) revealed multinodular varices in the third portion of the duodenum. Then we conducted a capsule endoscopy (CE) and found fresh blood in the duodenum, suggesting duodenal variceal hemorrhage. Angiography depicted the varices with one afferent and two efferent vessels. Abdominal CT examination was conducted using a four-channel multi-detector row CT scanner. The multiplanar reconstructed images revealed not only the varices, but also three afferent and two efferent vessels. The patient was treated by surgical ligation and sclerotherapy, because of its complicated porto-systemic shunt and reserved liver function. No gastrointestinal bleeding has bee...
Renal involvement in childhood-onset systemic lupus erythematosus in Egypt
This study aims to characterize the features and outcome of renal involvement in childhood-onset SLE based on a study of 100 Egyptian patients (mean age at diagnosis 10.1 years, range 2?17 years). Initial data regarding disease manifestations and biopsy findings were reviewed. Disease activity was assessed using SLEDAI scores. Follow-up data (mean duration 6 years) were noted regarding specific treatment, response, complications and renal survival. Initial renal involvement was present in 78 patients, including 66 with hypertension and 23 with renal impairment. Pathologically, class IV nephropathy was found in 18 patients, class V in 9 and low-grade lesions (class II?III) in 49. Twenty patients required follow-up biopsy, and all transformations were observed. SLEDA...
Secondary Ocular Hypertension After Intravitreal Injection with 2?mg or 4?mg of Triamcinolone in Retinal Vein Occlusion
Journal of Ocular Pharmacology and Therapeutics , Vol. 0, No. 0. (Source: Journal of Ocular Pharmacology and Therapeutics)
Association of dietary nutrient intakes in relation to progression of diabetic retinopathy in blacks with type I diabetes mellitus
The leading cause of blindness in diabetic people ages 20 to 64 years in the United States is complications of diabetic retinopathy (DR). Risk factors, including the duration of the disease, poor glycemic control, and systemic hypertension, have all been linked to progression of retinopathy. The American Diabetic Association (ADA) recommends restricting carbohydrate and fat intake for all patients with diabetes and restricting sodium intake for diabetic patients with hypertension. The investigators of the study evaluated the association of dietary nutrient intakes in relation to the 6-year progression of DR in blacks with type 1 diabetes mellitus. (Source: Optometry - Journal of the American Optometric Association)
Glomerular filtration rate measured by 51Cr-EDTA clearance: evaluation of captopril-induced changes in hypertensive patients with and without renal artery stenosis
CONCLUSIONS: Captopril induced a decrease in the GFR that could be quantitatively measured with 51Cr-EDTA. The reduction is more pronounced in hypertensive patients with RAS. (Source: Clinics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA. (Source: Brazilian Oral Research)
Lipins: multifunctional lipid metabolism proteins.
Authors: Csaki LS, Reue K The lipin proteins are evolutionarily conserved proteins with roles in lipid metabolism and disease. There are three lipin protein family members in mammals and one or two orthologs in plants, invertebrates, and single-celled eukaryotes. Studies in yeast and mouse led to the identification of two distinct molecular functions of lipin proteins. Lipin proteins have phosphatidate phosphatase activity and catalyze the formation of diacylglycerol in the glycerol-3-phosphate pathway, implicating them in the regulation of triglyceride and phospholipid biosynthesis. Mammalian lipin proteins also possess transcriptional coactivator activity and have been implicated in the regulation of metabolic gene expression. Here we review key findings in the field that demonstrate...
The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic Fatty liver disease associated with the metabolic syndrome.
Authors: Jornayvaz FO, Samuel VT, Shulman GI The metabolic syndrome is a clustering of cardiovascular risk factors, including insulin resistance, abdominal obesity, dyslipidemia, and hypertension, and is associated with other comorbidities such as a proinflammatory state and nonalcoholic fatty liver disease (NAFLD). Its prevalence is high, especially among developed countries, and mainly reflects overnutrition and sedentary lifestyle. Moreover, the developing countries are not spared, as obesity and its related problems such as the metabolic syndrome are increasing quickly. We review the potential primary role of skeletal muscle insulin resistance in the pathophysiology of the metabolic syndrome, showing that in lean, young, insulin-resistant individuals, impaired muscle glucose transp...
The effect of nutrition on blood pressure.
Authors: Savica V, Bellinghieri G, Kopple JD The incidence and severity of hypertension are affected by nutritional status and intake of many nutrients. Excessive energy intake and obesity are major causes of hypertension. Obesity is associated with increased activity of the renin-angiotensin-aldosterone and sympathetic nervous systems, possibly other mineralcorticoid activity, insulin resistance, salt-sensitive hypertension and excess salt intake, and reduced kidney function. High sodium chloride intake strongly predisposes to hypertension. Increased alcohol consumption may acutely elevate blood pressure. High intakes of potassium, polyunsaturated fatty acids, and protein, along with exercise and possibly vitamin D, may reduce blood pressure. Less-conclusive studies suggest that amino...
Dialysis More Likely than Death in Blacks (CME/CE)
African Americans with hypertension-associated kidney disease were more likely to develop end-stage renal disease (ESRD) than to die, researchers conducting a long-term cohort study said. (Source: MedPage Today Nephrology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Relationship Insecurity May Undermine Your Health
People who feel anxious and needy at higher risk of heart disease, high blood pressure, chronic pain and stroke, researchers find (Source: The Doctors Lounge - Cardiology)
First case of childhood Takayasu arteritis with renal artery aneurysms
We report a 12-year-old boy with Takayasu arteritis who developed severe hypertension, proteinuria, microscopic hematuria and renal dysfunction. Conventional angiography demonstrated aneurysms of both renal arteries and multiple microaneurysms of the superior mesenteric artery. This case report illustrates that the children with Takayasu arteritis can develop renal involvement resulting in hematuria, proteinuria and even renal failure. (Source: BioMed Central)
Unfavourable trends in cardiovascular and metabolic risk in paediatric and adult patients with congenital adrenal hyperplasia?
Conclusions Our findings suggest that adult CAH patients tend to have a cluster of metabolic risk factors, which are consistent with the metabolic syndrome. This notion may have consequences for the care for this group of patients. (Source: Clinical Endocrinology)
A Rare Cause of Recurrent Hematuria in Children: Nutcracker Syndrome
We report a 6-year-old girl with episodic macroscopic hematuria who was diagnosed as NCS with Doppler ultrasound and 3D computerized tomography angiography. She was managed conservatively with spontaneous resolution of macroscopic hematuria. With this case we would like to emphasize that in children with hematuria and orthostatic proteinuria without an apparent cause, a great index of suspicion and appropriate imaging is necessary for the diagnosis of NCS. (Source: Journal of Tropical Pediatrics)

factors for hypertension can be controlled effectively by your lifestyle choices. For example, excess weight and lack of exercise can lead to high blood pressure. So can tobacco use, excess alcohol consumption and chronic stress. By making good lifestyle choices that avoid as many of these risk factors as possible, you can do much to reduce your chances of developing dangerous hypertension. You may also have a higher risk of developing hypertension at some time in your life if you have a family history of this condition.

High Blood Pressure Treatments

The proper treatment of hypertension is important, even if you are not feeling bad. Since high blood pressure can increase your risk of other serious health problems, controlling your blood pressure is an important step to a healthier you. Lifestyle changes and medication is often the first step in controlling hypertension, and there are many prescription drugs that your doctor can prescribe to find the one that works the best for you.

In addition to medication, lifestyle changes are an effective way to keep your blood pressure under control. A healthy diet that is rich in whole grains, fruits and vegetables is a good first step, coupled with thirty minutes of daily physical activity that will keep your cardiovascular system strong and healthy. These two steps will also help you to maintain a healthy weight, which is another positive step in controlling blood pressure. Quitting smoking, limiting alcohol intake and learning to manage your stress effectively are other good choices for lower blood pressure. Getting serious about your health is an important step in keeping your hypertension under control and enjoying a healthier lifestyle overall.

Also there are many natural ways to help lower your blood pressure without the use of drugs.

Hypertension & High Blood Pressure Articles..

Salt And Hypertension – The Dangerous Combination
By Nancy Drew
It has been observed that there is indeed a close connection between salt (sodium) and hypertension as the more salt you consume, the higher your blood pressure would shoot up. Of Read more...

Hypertension Medications Information
Hypertension Medications Such As Combipres Have Been Proven To Be Effective In case you are looking for effective hypertension medications then it would be worth checking out one Read more...